in-frame deletions of exon 19 and L858R substitution in exon 21) and -resistant (e.g., T790M in exon 20) mutations depending on the patient’s response to EGFR-TKI therapeutics1. The most prevalent EGFR kinase domain mutations are the in-frame deletions of exon 19 ...
aMutations in EGFR—either small in-frame deletions in exon 19 or aminoacid substitution (leucine to arginine at codon 858 [L858R]) clustered around the ATP-binding pocket of the tyrosine kinase domain—are present in 10–26% of non-small-cell lung cancer (NSCLC)tumours and are associated ...
aMutations in EGFR—either small in-frame deletions in exon 19 or aminoacid substitution clustered around the ATP-binding pocket of the tyrosine kinase domain—are present in 10–26% of non-small-cell lung cancer (NSCLC)tumours and are associated with response to gefi tinib and erlotinib. ...
The most common EGFR mutations, including in-frame deletions in exon 19 and base substitutions in exon 21, were detected by denaturing high performance liquid chromatography (DHPLC) and direct sequencing simultaneously. K-RAS mutations in codons 12 and 13 were detected by direct sequencing. In ...
文中列举了EGFR 19del变异的所有亚型(图1),按氨基酸缺失起始位置分,发现相比L747del亚型(从L747位置缺失),E746del亚型(从E746位置缺失)具有更长的OS、更长的PFS和更高的T790M获得性突变率,尤以E746_A750del最为显著。 图1. EGF...
reported mutations that produced in-frame deletions of amino acids from the triple-helical domain of type-I collagen indicated that deletions in the N-terminal half of the alpha 2(I) chain tended to produce milder phenotypes than similar deletions elsewhere in the alpha 1(I) or alpha 2(I) ...
It is well established that classic mutations, such as in-frame deletions in exon 19 and the point mutation L858R in exon 21, are associated with high sensitivity to EGFR TKIs. Though mutations in exon 20 are almost correlated with EGFR-TKIs resistance, the awareness that they might confer ...
Patients with activatingEGFRmutations are identified in ~20% of lung adenocarcinomas in Western countries9and 40~60% of lung adenocarcinomas in East Asia10,11,12. These mutations mainly consist of in-frame deletions in exon 19 (~50%) and the L858R point mutation in exon 21 (~40%)9and the...
Polymorphic sites in the region of interest (Chr17:60,000,000 bp – 70,000,000 bp) including short insertions and deletions were called for the two animals sequenced together with 43 previously sequenced Fleckvieh (FV) key ancestors [13] using the multi-sample approach implemented in mpileup...
A deletion of exons 6–8 is predicted to result in an in-frame but shortened product, with the SDR domain largely missing. (16 years) with irregular menstruation up to the first pregnancy. Before this pregnancy she had received hormonal stimulation, but this was stopped before conception. ...