必应词典为您提供in-frame-deletions的释义,网络释义: 阅读框架内的缺失;缺失突变株;框内缺失;
n. 删除;[网络] 缺失; 删减; 删除;[例句]This metadata stores information about the creation, versioning, and deletion of items.该元数据存储了关于创建、版本和删除项的信息。[其他] 复数：deletions 形近词： deleting
3.Objective To characterize the deletions of mitochondrial DNA (mtDNA) in Chinese patients with Kearns-Sayre syndrome (KSS) and chronic progressive external ophthalmolegia (CPEO) and identify deletion mutations of mtDNA be the etiology of these diseases.在2例Kearns-Sayre综合征(KSS)和2例慢性进行性...
Most frequently, these are deletions leading to reading-frame shift. The "reading-frame rule" states that deletions that preserve ORF result in a milder Becker muscular dystrophy. By removing several exons, new genome editing tools enable reading-frame restoration in DMD with the...
no vector backbone was left behind and only the mutant copy of the gene is present. You should expect a ratio no greater than 50:50 wild type to mutant.Notes:-We have found that making in-frame deletions in a standard cloning vector first (outside of pCRPrtNeo) works much better ...
The three intragenic OPHN1 deletions include multiple exons, which remove at least parts of the BAR domain. It is unknown, however, whether these deletions result in in-frame losses, as observed in our family. The presence of microhomology at the junction of the deletion in our family could ...
where the two most prevalent types of mutations are in-frame deletions in exon 19 (i.e., E19del) and an L858R point mutation in exon 21; the latter mutations account for less than 85% of all mutations1,33,34. Because of the heterogeneous nature of intra-tumor development, it was nece...
aMutations in EGFR—either small in-frame deletions in exon 19 or aminoacid substitution (leucine to arginine at codon 858 [L858R]) clustered around the ATP-binding pocket of the tyrosine kinase domain—are present in 10–26% of non-small-cell lung cancer (NSCLC)tumours and are associated ...
A general method is presented for randomly mutagenizing open reading frames (ORF) to generate in-frame deletions and insertions. The protocol requires expression of the ORF of interest as a hybrid ORF-beta-galactosidase fusion protein. This allows colorimetric screening for beta-galactosidase activity...
(4%) had small in-frame deletions. Seven mutations occurred multiple times. All of them are C to T transitions that affect CpG dinucleotides, suggesting that their multiple occurrence is due to the hypermutability of this sequence. All mutations, including the two deletions, result in the gain...