必应词典为您提供in-frame-deletions的释义,网络释义: 阅读框架内的缺失;缺失突变株;框内缺失;
3.Objective To characterize the deletions of mitochondrial DNA (mtDNA) in Chinese patients with Kearns-Sayre syndrome (KSS) and chronic progressive external ophthalmolegia (CPEO) and identify deletion mutations of mtDNA be the etiology of these diseases.在2例Kearns-Sayre综合征(KSS)和2例慢性进行性...
n. 删除;[网络] 缺失; 删减; 删除;[例句]This metadata stores information about the creation, versioning, and deletion of items.该元数据存储了关于创建、版本和删除项的信息。[其他] 复数：deletions 形近词： deleting
no vector backbone was left behind and only the mutant copy of the gene is present. You should expect a ratio no greater than 50:50 wild type to mutant.Notes:-We have found that making in-frame deletions in a standard cloning vector first (outside of pCRPrtNeo) works much better ...
The otopalatodigital syndrome spectrum is caused by distinct FLNA missense mutations or in-frame deletions disrupting the development of craniofacial and long bones. We report on a clinical, neuroimaging, X-ray, and molecular study of a family in which classical bilateral PH appeared as an ...
It is unknown, however, whether these deletions result in in-frame losses, as observed in our family. The presence of microhomology at the junction of the deletion in our family could point to the rearrangement mechanism being non- homologous end joining or MMBIR. The DNA repair mechanism of...
where the two most prevalent types of mutations are in-frame deletions in exon 19 (i.e., E19del) and an L858R point mutation in exon 21; the latter mutations account for less than 85% of all mutations1,33,34. Because of the heterogeneous nature of intra-tumor development, it was nece...
aMutations in EGFR—either small in-frame deletions in exon 19 or aminoacid substitution (leucine to arginine at codon 858 [L858R]) clustered around the ATP-binding pocket of the tyrosine kinase domain—are present in 10–26% of non-small-cell lung cancer (NSCLC)tumours and are associated ...
(4%) had small in-frame deletions. Seven mutations occurred multiple times. All of them are C to T transitions that affect CpG dinucleotides, suggesting that their multiple occurrence is due to the hypermutability of this sequence. All mutations, including the two deletions, result in the gain...
A general method is presented for randomly mutagenizing open reading frames (ORF) to generate in-frame deletions and insertions. The protocol requires expression of the ORF of interest as a hybrid ORF-beta-galactosidase fusion protein. This allows colorimetric screening for beta-galactosidase activity...