Successful treatment of epidermal growth factor receptor exon 19 deletion non-small cell lung cancer with almonertinib after osimertinib-induced interstitial lung disease: A case reportdoi:10.4103/jcrt.jcrt_2235_24Almonertinibinterstitial lung disease...
Experimental Design: Tumor specimens obtained before treatment with gefitinib or erlotinib were analyzed for EGFR mutations. Patients with exon 19 deletion or L858R mutations were identified. The response rate, time to progression, and overall survival were determined for the two groups. Results: ...
In this NMA, osimertinib and SoC combined with chemotherapy would be the optimal first-line treatment options for advanced NSCLC patients harboring EGFR 19 deletion mutation and 21 Leu858Arg mutation, respectively. This finding is likely to be adopted in clinical practice and provide guidance for ...
Lung cancer has traditionally been classified by histology. However, a greater understanding of disease biology and the identification of oncogenic driver alterations has dramatically altered the therapeutic landscape. Consequently, the new classification paradigm of non–small-cell lung cancer is further ch...
Sequence alignments of WT- and MT-alleles for the in-frame deletion ofEGFRE19del. The solid-line boxes indicate the positions of the Ef- and Er-primer, The dotted-line boxes indicate the positions of the LST oligonucleotides. The gray-highlighted letters indicate the positions of the WTB oli...
目的 研究表皮生长因子受体(EGFR)外显子19缺失突变(EGFR exon 19 deletion)在恶性甲状腺肿瘤中促侵袭转移的作用.方法 划痕和Transwell实验检测细胞的迁移和侵袭能力;... 张晶晶,夏玉娟,董顺利,... - 《中国血液流变学杂志》 被引量: 0发表: 2021年 Investigation of the epidermal growth factor receptor mutation...
surgically resected non-small cell lung cancer Ying Jin1,2, Ming Chen2,3 & Xinmin Yu1 The clinical behavior of patients with advanced non-small cell lung cancer (NSCLC) differ between epidermal growth factor receptor (EGFR) exon 19 deletion (Ex19) and EGFR exon 21 L858R mutation (...
Of the 240 patients with T790 M mutations, 213 patients showed results consistent with the mutation analysis before TKI treatment, and the rate of patients with the L858R point mutation along with the T790 M mutation was lower than that of patients with the exon 19 deletion (36.42% to 58.30...
leptin targets hippocampal neurons to regulate depression-related behaviors. First, direct infusion of leptin into the dentate gyrus of the hippocampus induces an antidepressant-like effect, similar to the effect observed after systemic injection [15]. Second, deletion of LepRb in the dentate gyrus ...
treatment with anti-EGFR monoclonal antibodies, concurrent EGFR mutations that were reported to be responsive to approved EGFR tyrosine kinase inhibitor (TKI) (eg, exon 19 deletion, L858R, T790M, L861Q, G719X, S768I), use of immune checkpoint inhibitors within 3 months (for JMT101+Osimerit...