The present invention relates to novel compounds of formula (I), which is capable of inhibiting one or more kinases, in particular inhibition of SYK (Spleen tyrosine kinase), of LRRK2 (leucine-rich repeat kinase 2) and / or MYLK (myosin MLCK) or a mutant thereof. 所述化合物可用于治疗...
Targeted therapy drugs like tyrosine kinase inhibitors (TKIs) specifically inhibit the activity of the BCR-ABL fusion protein, leading to the suppression of leukemic cell growth. These drugs have significantly improved outcomes and transformed CML from a life-threatening condition into a manageable chron...
ofFGFR一1ldnase.@2014FangXiaoandIJanLi.PublishedbyElsevierB.V.orlbehalfofChineseChemicalSociety.A1lrightsreserved.Thefibroblastgrowthfactorreceptor1fFGFR一1】isatransmembranetyrosinekinasereceptor(TKR)thatbelongstotheimmunoglobulin(Ig)superfamilyf11.FGFR一1wasfirstclonedandidentifiedbyLeeeta1..asamemberoftheFGFR...
They are: helenalin and its analogues, antitumor agents that act as modulators of Ca2+ signalling; wortmannin and its analogues, inhibitors of phosphati-dylinositol-3-kinase; and gallium nitrate, a clinically used antitumor drug that is an inhibitor of a protein tyrosine phosphatase.Keywords:: ...