Because this new class of drugs is extensively used, serious drug-drug interactions are an increasing risk. In this Review, we give a comprehensive overview of known or suspected drug-drug interactions between tyrosine-kinase inhibitors and other drugs. We discuss all haemato-oncological and ...
2015 Published: 08 December 2015 Drug-Drug Interaction Potentials of Tyrosine Kinase Inhibitors via Inhibition of UDP- Glucuronosyltransferases Nan Zhang3, Yong Liu4 & Hyunyoung Jeong1,2 Tyrosine kinase inhibitors (TKIs) are anticancer drugs that may be co-administered with other drugs. ...
Kinase inhibitors are drugs that generally inhibit tyrosine kinase (TK) enzymes, which catalyze the transfer of phosphate groups from adenosine triphosphate (ATP) to tyrosine residues on proteins.14This process can be an activating event for proteins involved in signaling, and leads to increased cellu...
The clinical benefit of tyrosine kinase inhibitors (TKIs)-based systemic therapy for advanced hepatocellular carcinoma (HCC) is limited due to drug resistance. Here, we uncover that lipid metabolism reprogramming mediated by unconventional prefoldin RPB5 interactor (URI) endows HCC with resistance to TK...
In the past decade, many tyrosine-kinase inhibitors have been introduced in oncology and haemato-oncology. Because this new class of drugs is extensively used, serious drug–drug interactions are an increasing risk. In this Review, we give a comprehensive overview of known or suspected drug–drug...
tyrosine kinase inhibitor Thesaurus Medical Acronyms Wikipedia n. Any of a class of drugs, such as imatinib, that target and block the action of specific tyrosine kinases and are used especially in the treatment of chronic myelogenous leukemia and other cancers. ...
Tyrosine kinase inhibitors (TKIs) are indicated for the treatment of a variety of malignancies due to their ability to interfere with cell communication and growth. Interactions that affect TKI metabolism are discussed. Dasatinib (Sprycel), erlotinib (Tarceva), gefitinib (Iressa), imatinib (Gleevec)...
Epidermal growth factor tyrosine kinase inhibitors (EGFR-TKIs) : simple drugs with a complex mechanisim of action? Normanno N,Maiello MR,De Luca A.Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs): simple drugs with a complex mechanism of action... N Normanno - 《Journal...
Biological activity of tyrosine kinase inhibitors: novel agents for psoriasis therapy. Curr. Opin. Investig. Drugs 2, 1539–1545 (2001). CAS PubMed Google Scholar Ben-Bassat, H. Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. J. Pharmacol. ...
tyrosine kinase inhibitors (TKIs), target-specific inhibitors of PTKs, have been used in treating malignant tumors and play a significant role in targeted therapy of cancer. Currently, drug resistance is the main reason for limiting TKIs efficacy of cancer. The increasing studies indicated that tumo...