TYROSINE KINASE INHIBITORSIMATINIBThe editors would like to express their gratitude to members of the advisory board and to the following for their work as referees for Acta Analytica: Abell, Catharine Arrieta, Agustin Arsenijevi, Milo Bakalova, Marina Baker, Lynne Battaly, Heather Baumann, Peter ...
Olverembatinib is an orally-available third-generation tyrosine kinase inhibitor (TKI), and the first China-approved third-generation BCR-ABL inhibitor that can effectively target BCR-ABL and a spectrum of BCR-ABL mutants, including the T315I mutation. At present, olverembatinib has been approve...
Kinase inhibitors also known astyrosinekinase inhibitors (TKIs) are potent anticancer drugs. They disrupt the signal transduction pathways of enzyme tyrosine kinases which are involved in cell growth, migration, differentiation,apoptosis, and cell death. These drugs are used for the treatment of patient...
Anaplasticlymphomakinase (ALK) inhibitors are a class of drugs used to treat adult patients with ALK-positive metastatic nonsmall cell lung cancer (NSCLC) that has spread to nearby tissues or other parts of the body. They are “tyrosinekinase inhibitors” that selectively and potently inhibit ALK...
1. Lai D et al. (2018) PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia. Science Translational Medicine 10(427). 2. Minzel W et al. (2018) Small molecules co-targeting CKIα and the transcriptional kinases CDK7/9 control AML in ...
aEGFR tyrosine kinase inhibitors (TKI), such as erlotinib and gefitinib, were initially evaluated without molecular selection in patients with relapsed NSCLC. EGFR tyrosine kinase 抑制剂 (TKI),例如 erlotinib 和 gefitinib,用被重新陷入的 NSCLC 没有在病人中的分子的精选品地最初被评价。 [translate] a...
Key words: Cells, Genetics, Inhibitation, Inhibitors, Peptides and Proteins [more] Organism: Human Tissue: Colon Pathological State: Cancer 36 Application of Small Animal Ultrasound Imaging Technology for Identification of Polycystic Ovary Syndrome in a Mouse Model M Ren, T Yang, M Liu, X Ma...
Imaging the Intracellular Distribution of Tyrosine Kinase Inhibitors in Living Cells with Quantitative Hyperspectral Stimulated Raman Scattering D. Fu, J. Zhou, W.S. Zhu, P.W. Manley,Y.K. Wang, T. Hood, A. Wylie, X.S. Xie Nat Chem. 2014 Jul; 6(7): 614–622. doi: 10.1038/nchem....
Zhao J, Zhuo M, Wang Y, Wang S, Zang W, Wu M, An T, Rao G, Zhu G, Wang J.Potential Resistance Mechanisms Revealed by Targeted Sequencing from Lung Adenocarcinoma Patients with Primary Resistance to Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors (TKIs).J Thorac O...
There has been a great deal of interest in understanding the role of tyrosine-specific protein kinases encoded by the transforming viruses and their normal cellular homologues and exploring their potential as therapeutic targets. Thus, BCR-ABL tyrosine kinase inhibitors have started era of molecular ...