Evolution of antimicrobial resistance and nosocomial infection: lessons from the Vanderbilt experience. Am J Med 1981;70:445-448.Schaberg DR, Rubens CE, Alford RH, et al: Evolution of antimicrobial resistance an
The rise of antimicrobial resistance as a global health concern has led to a strong interest in compounds able to inhibit the growth of bacteria without detectable levels of resistance evolution. A number of these compounds have been reported in recent years, including the tridecaptins, a small ...
Fig. 1: Community interactions, as well as resistance genotype, affect the response to antibiotic exposure. Full size image Ecological context can influence the selection for antimicrobial resistance Fig. 2: Fitness and selection consequences of differential effects of antibiotic concentration on growth ...
How bacteria live — whether as independent cells or in a communal biofilm — determines how they evolve antibiotic resistance, which could lead to more personalized approaches to antimicrobial therapy and infection control. University of Pittsburgh School of Medicine researchers repeatedly exposed bacteria...
I. Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance. Science 287, 1479–1482 (2000). Article Google Scholar Petersen, A., Aarestrup, F. M. & Olsen, J. E. The in vitro fitness cost of antimicrobial resistance in Escherichia coli varies with the ...
An Oxford University study has found that multiple pathogen clones in patients lead to faster antimicrobial resistance (AMR), rather than the evolution of new resistance mutations in a single strain, challenging traditional AMR perspectives. The study proposes that interventions focusing on preventing bac...
biopsies were obtained by 62 gastroenterologists randomly selected in 5 regions of France and sent to a central laboratory where culture, antimicrobial susceptibility testing, and a real‐time PCR were performed in order to detect H pylori and its mutations associated with clarithromycin resistance. Du...
We analyzed the evolutionary pattern of cysteine-rich peptides (CRPs) to infer the relationship between CRP copy number and plant ecotype, and the origin of bi-domains CRPs. Abstract Plants produce cysteine-rich peptides (CRPs) that have long-lasting broad-spectrum antimicrobial activity to protect...
The evolution of antibiotic resistance is becoming not only a clinical problem for the therapy of infectious diseases, and hence for the progress of medicine, the effect of antibiotics on the microbiosphere might also result in unexpected global ecological effects, producing changes in the structure ...
The objective of this study was to investigate the evolution of antibiotic resistance phenotypes, antibiotic resistance genes (ARGs) and Class 1 integron of Salmonella in municipal wastewater treatment plants (WWTPs). A total of 221 Salmonella strains were isolated from different stages of three WWTPs...