The evolution of antimicrobial resistance (AMR) has mainly been studied in planktonic bacteria exposed to sub-inhibitory antimicrobial (AM) concentrations. However, in a number of infections that are treated with AMs the bacteria are located in biofilms where they tolerate high ...
Fig. 1: Community interactions, as well as resistance genotype, affect the response to antibiotic exposure. Full size image Ecological context can influence the selection for antimicrobial resistance Fig. 2: Fitness and selection consequences of differential effects of antibiotic concentration on growth ...
During the past 50 years, the permanent increase in bacterial resistance to antibiotics has led to modifications in therapeutic recommendations. Despite evidence that antimicrobial exposure of human populations is the most important driving force for the continuous increase in bacterial resistance, the stud...
The aim of this study was to investigate the evolution of antimicrobial resistance in EAEC and ETEC causing diarrhoea in patients who had travelled to different developing countries, comparing two periods of time, 1994-97 and 2001-04. Overall, 134 EAEC and 190 ETEC clinical isolates were studied...
The first decade of the 20th century witnessed a surge in the incidence of infections due to several highly antimicrobial-resistant bacteria in hospitals worldwide.Acinetobacter baumanniiis one such organism that turned from an occasional respiratory pathogen into a major nosocomial pathogen. An increasin...
World-wide spread of bacterial resistance to antimicrobial agents may limit the future progress of medicine. A huge environmental antibiotic pressure, resulting from industrial production and marketing of these drugs, has simultaneously contributed to the increase in the diversity of resistant phenotypes, ...
Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistanceExperimental evolutionAntibioticsAntimicrobial resistanceEvolvabilityGenetic perturbations that affect bacterial resistance to antibiotics have been characterized genome-wide, but how do such perturbations interact with...
(2012). Evolution of antibiotic resistance at non-lethal drug concentrations. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 15(3), 162-172.Andersson, D.I., Hughes, D., 2012. Evolution of antibiotic resistance at non-lethal drug concentrations. ...
Evolution of antimicrobial resistance in H-pylori Spanish clinical isolates in a 10-year period Lynch JP 3rd, Zhanel GG (2010) Streptococcus pneumoniae : epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccines. Curr... MJ Moreno,T Alarcon,S Agudo,... - Inte...
Understanding the conditions that favour the evolution and maintenance of antibiotic resistance is the central goal of epidemiology. A crucial feature explaining the adaptation to harsh, or 'sink', environments is the supply of beneficial mutations via migration from a 'source' population. Given that...