This chapter discusses the evolution of antibiotic resistance. Antibiotic resistance refers to the property of bacteria which prevents the inhibition of their growth by antimicrobial agents used in the clinical setting. Resistance can thus be achieved either if the antibiotic concentration reaching the ...
Hall, B. G. 2004. Predicting the evolution of antibiotic resistance genes. Nat Rev Microbiol 2:430-435.Hall B G.Predicting the evolution of antibiotic resistancegenes. Nature Reviews Microbiology . 2004Hall BG (2004) Predicting the evolution of antibiotic resistance genes. Nat Rev Microbiol 2:...
Hall BG (2004) Predicting the evolution of antibiotic resistance genes. Nat Rev Microbiol 2:430–435Hall, B.G. 2004. Predicting the evolution of antibiotic resis- tance genes. Nat. Rev. Microbiol. 2:430-435.Hall BG. 2004. Predicting the evolution of antibiotic resistance genes. Nat Rev ...
relevant levels of resistance. Subsequent evolution occurred by mutations in a regulatory RNA that increased the plasmid copy number, resulting in marginal gains in ceftazidime resistance. These results uncover a role for multicopy plasmids as catalysts for the evolution of antibiotic resistance in bacter...
evolution. But how do such targeted perturbations of cellular functions interact with the subsequent evolutionary adaptation to drugs? The genetic background determines the effects of resistance mutations, which can enable or block specific mutational paths to drug resistance. For example, the ...
Drug interactions and the evolution of antibiotic resistance. Large-scale, systems biology approaches now allow us to systematically map synergistic and antagonistic interactions between drugs. Consequently, drug anta... Yeh,J Pamela,Hegreness,... - 《Nature Reviews Microbiology》...
The evolution of antibiotic resistance carries a fitness cost, expressed in terms of reduced competitive ability in the absence of antibiotics. This cost p... T Vogwill,RC Maclean - 《Evolutionary Applications》 被引量: 97发表: 2014年 Quantifying Deception: A Case Study in the Evolution of Ant...
Evolution of antibiotic resistance in microbes is frequently achieved by acquisition of spontaneous mutations during antimicrobial therapy. Here, we demonstrate that inactivation of a central transcriptional regulator of iron homeostasis (Fur) facilitates laboratory evolution of ciprofloxacin resistance in Escheri...
of original scientific and technical breakthroughs. In 2024, the Chang’e 6 probe successfully landed in the Apollo basin in the southern hemisphere and brought back lunar soil from the far side of the moon for the first time. This provided...
Evolution of Resistance to Antibiotics in Bacteria Presented by Jana Boozer Katelin Erwin Ashley Gregory Sara Thompson What is antibiotic resistance? Antibiotic resistance occurs when an antibiotic has lost its ability to effectively control or kill bacterial growth; in other words, the bacteria are "...