In this Review, Smith, Foster and colleagues explore the protective strategies of bacteria, including the mechanisms, evolution and clinical implications of these ancient defences. They discuss new therapies for treating disease and how to minimize resistance evolution.doi:10.1038/s41579-023-00877-3Smith, William P. J.Wucher, B...
Bacterial evolution: Historical influences on antibiotic resistanceNewer quinolones, including garenoxacin, are characterized by excellent activity against gram-negative bacteria along with high activity against gram-positive organisms. All the new quinolones have similar in vitro potencies against most gram...
Unlike resistance, however, the monoclonal heteroresistant phenotype is unstable, and cells revert to the antibiotic-sensitive state when the antibiotic pressure drops. A major distinction between persistence and heteroresistance is that persister cells do not grow during antibiotic therapy, while hetero...
However, little is known whether these sweeteners could be associated with risks such as antimicrobial effect and bacterial evolution of antibiotic resistance/tolerance. In the present study, we found that four commonly used Conclusions This study for the first time demonstrates that all four commonly...
University of Pittsburgh School of Medicine researchers repeatedly exposed bacteria to the antibiotic ciprofloxacin to force rapid evolution. As expected, the bacteria developed resistance to the drug, but surprisingly, their lifestyle affected which specific adaptations emerged, according to a study publish...
On the other hand, increasing research has highlighted that the metabolic state of the cell also impacts all aspects of antibiotic biology, from drug efficacy to the evolution of antimicrobial resistance (AMR). Given that AMR is a growing threat to the current global antibiotic arsenal and ...
When it comes to bacteria, a careful observer can track evolution in the span of a few days. Because of how quickly bacteria grow, it only takes days for bacterial strains to acquire new traits or develop resistance to antimicrobial drugs. ...
describing the evolution of antibiotic resistance by imposing certain biological attributes of resistant and sensitive strains of bacteria on the SIS model. The problem posed is one of optimal use of a non-renewable resource. In a simple non-renewable resource model with variable costs ...
Althoughpneumococcalvaccineshavehelped,serotypeshiftsandbacterialresistancecouldworkagainstcurrenttreatmentpractices. 虽然肺炎球菌疫苗有帮助,血清型转变和细菌耐药性的工作可以对目前的治疗方法。 www.syyxw.com 7. The needfornew ways tocontrolbacteriareflects therapidevolutionandspreadofbacterialresistanceto the mostpow...
Bacteria can undergo adaptive evolution during severe infections, leading to treatment failure. The authors use within-host evolution genomic analysis to investigate persistent Staphylococcus aureus infections and optimise antibiotic treatment. Stefano G. Giulieri Marcel Leroi Benjamin P. Howden ResearchOpen...