Persisters are transiently antibiotic-tolerant cells that complicate the treatment of bacterial infections. Both theory and experiments have suggested that persisters facilitate genetic resistance by constituting an evolutionary reservoir of viable cells. Here, we provide evidencefor a strong positive ...
EvolutionAntibiotic treatment failure is of growing concern. Genetically encoded resistance is key in driving this process. However, there is increasing evidence that bacterial antibiotic persistence, a non-genetically encoded and reversible loss of antibiotic susceptibility, contributes to treatment failure ...
University of Pittsburgh School of Medicine researchers repeatedly exposed bacteria to the antibiotic ciprofloxacin to force rapid evolution. As expected, the bacteria developed resistance to the drug, but surprisingly, their lifestyle affected which specific adaptations emerged, according to a study publish...
Unlike resistance, however, the monoclonal heteroresistant phenotype is unstable, and cells revert to the antibiotic-sensitive state when the antibiotic pressure drops. A major distinction between persistence and heteroresistance is that persister cells do not grow during antibiotic therapy, while hetero...
The relationship between bacterial metabolism and antibiotic treatment is complex. On the one hand, antibiotics leverage cell metabolism to function. On the other hand, increasing research has highlighted that the metabolic state of the cell also im
Biofilms may be avoided and cured with vigorous antibiotic prophylaxis or treatment early on and with continuous suppressive medication. This review discusses the development of antibiotic resistance and tolerance in bacteria due to biofilm formation, the tolerance mechanisms, and the development of ...
When it comes to bacteria, a careful observer can track evolution in the span of a few days. Because of how quickly bacteria grow, it only takes days for bacterial strains to acquire new traits or develop resistance to antimicrobial drugs. ...
describing the evolution of antibiotic resistance by imposing certain biological attributes of resistant and sensitive strains of bacteria on the SIS model. The problem posed is one of optimal use of a non-renewable resource. In a simple non-renewable resource model with variable costs ...
Althoughpneumococcalvaccineshavehelped,serotypeshiftsandbacterialresistancecouldworkagainstcurrenttreatmentpractices. 虽然肺炎球菌疫苗有帮助,血清型转变和细菌耐药性的工作可以对目前的治疗方法。 www.syyxw.com 7. The needfornew ways tocontrolbacteriareflects therapidevolutionandspreadofbacterialresistanceto the mostpow...
cells. This is due to a combination of enhanced mutation rate, increased adhesion capacity and protective biofilm-associated tolerance. These results show that the biofilm environment favors rapid evolution of resistance and provide new insights into the dynamic evolution of antibiotic resistance in ...