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The evolution of antibiotic resistance is one of the most serious challenges facing modern healthcare [1], causing over 1.2 million deaths and tens of millions of extra days in recovery per year [2,3]. While the evolution of antibiotic resistance has been extensively studied in laboratory monoc...
and marketing of these drugs, has simultaneously contributed to the increase in the diversity of resistant phenotypes, to the selection of the fittest among them, and to the dispersal of resistance genes, which is expected to result in a significant acceleration of the rate of microbial evolution...
Antibiotic resistance: adaptive evolution. The article discusses antibiotic resistance as a result of the evolutionary selection pressure created by the extensive use of antibiotics. The mutability ... Salmond,PC George,Welch,... - 《Lancet》 被引量: 24发表: 2008年 Antibiotic Resistance: Adaptive ...
, Antibiotic resistance: origins, evolution, selection and spread. Ciba Foundation Symposium 207. Wiley, Chichester, N.Y.Witte W. Impact of antibiotic use... W Witte - 《Ciba Found Symp》 被引量: 91发表: 2007年 Comparative Genomics of Environmental and Clinical Stenotrophomonas maltophilia Strains...
Lacey RW. Evolution of microorganisms and antibiotic resistance. Lancet.1984Nov3;2(8410):1022-5.Lacey R W, (1984). Evolution of microorganisms and antibiotic resistance. Lancet; 2: 1022-1025.Lacey RW. Evolution of microorganisms and antibiotic resist- ance. Lancet 1984;ii:1022-5....
The intensity and character of concerns about antibiotic resistance, over the past nearly seventy-five years, have depended on a series of linked factors: the evolution and distribution of resistant microbes themselves; our differential capacity and efforts to detect such microbes; evolving models of ...
Furthermore, theoretical models and new experiments suggest that antagonistic interactions between antibiotics can counteract the evolution of drug resistance.关键词:interactions evolution resistance DOI: 10.1111/j.1365-246X.2007.03459.x 被引量: 743 ...
Revealing the genetic changes responsible for antibiotic resistance can be critical for developing novel antibiotic therapies. However, systematic studies correlating genotype to phenotype in the context of antibiotic resistance have been missing. In order to fill in this gap, we evolved 88 isogenic Esch...
“Antibiotic resistance is one of our main problems in medicine,” Santos-Lopez said. “We have to develop new treatments, and one idea is to take advantage of what the field calls ‘collateral sensitivity.’ When bacteria evolve resistance to one drug, it can expose a vulnerability to a di...