and marketing of these drugs, has simultaneously contributed to the increase in the diversity of resistant phenotypes, to the selection of the fittest among them, and to the dispersal of resistance genes, which is expected to result in a significant acceleration of the rate of microbial evolution...
and marketing of these drugs, has simultaneously contributed to the increase in the diversity of resistant phenotypes, to the selection of the fittest among them, and to the dispersal of resistance genes, which is expected to result in a significant acceleration of the rate of microbial evolution...
Here, we find that RNAP stalling plays an important role in causing DNA damage and promoting resistance evolution. In many prokaryotes, the leading ribosome on nascent mRNA is in physical contact with the transcribing RNAP, which contributes to the normal processivity of the latter19,20. This t...
The evolution of antibiotic resistance is one of the most serious challenges facing modern healthcare [1], causing over 1.2 million deaths and tens of millions of extra days in recovery per year [2,3]. While the evolution of antibiotic resistance has been extensively studied in laboratory monoc...
, Antibiotic resistance: origins, evolution, selection and spread. Ciba Foundation Symposium 207. Wiley, Chichester, N.Y.Witte W. Impact of antibiotic use... W Witte - 《Ciba Found Symp》 被引量: 91发表: 2007年 Comparative Genomics of Environmental and Clinical Stenotrophomonas maltophilia Strains...
The evolution of bacterial pathogens towards antibiotic resistance is not just a relevant problem for human health, but a fascinating example of evolution that can be studied in real time as well. Although most antibiotics are natural compounds produced by environmental microbiota, exposure of bacterial...
The legacy of the use and misuse of antibiotics in recent decades has left us with a global public health crisis: antibiotic-resistant bacteria are on the rise, making it harder to treat infections. At the same time, evolution of antibiotic resistance is probably the best-documented case of ...
Natural ecosystems contain a large number of potential resistance genes; nevertheless, just a few of them are currently present in gene-transfer units and disseminated among pathogens. Along the review, the processes implied in this situation and the consequences for the future evolution of resistance...
Infections, especially peritoneal dialysis-related peritonitis, are unavoidable because of lapses in technique and the slow worsening of systemic and peritoneal defense associated with aging and dialysis. The selective pressure inherent in the use of antibiotics shapes the pattern of antibiotic resistance ...
Furthermore, theoretical models and new experiments suggest that antagonistic interactions between antibiotics can counteract the evolution of drug resistance.关键词:interactions evolution resistance DOI: 10.1111/j.1365-246X.2007.03459.x 被引量: 743 ...