ETV6-RUNX1 interacts with a region in SPIB intron 1 to regulate gene expression in pre-B cell acute lymphoblastic leukemiaThe most frequently occurring genetic abnormality in pediatric B-lymphocyte-lineage acute lymphoblastic leukemia is the t(12;21) chromosomal translocation that results in a ETV6...
As few ETV6-RUNX1 carriers develop precursor B-cell acute lymphocytic leukemia (pB-ALL), the underlying genetic basis for development of full-blown leukemia remains to be identified, but the appearance of leukemia cases in time-space clusters keeps infection as a potential causal factor. Here, ...
The reciprocal translocation t(12;21)(p13;q22), the most common structural genomic alteration in B-cell precursor acute lymphoblastic leukaemia in children, results in a chimeric transcription factor TEL-AML1 (ETV6-RUNX1). We identified directly and indirectly regulated target genes utilizing an ind...
Here, we show by using biotinylated erythropoietin (EPO) and flow analysis that the pre-B ALL TEL-AML1+ cell line (REH) appeared to have higher levels of EPO receptor than other non-TEL-AML1 cell lines. Furthermore, when we "blind screened" CD19+ peripheral blood or bone marrow cells...
Modeling the evolution of ETV6-RUNX1–induced B-cell precursor acute lymphoblastic leukemia in mice - ScienceDirect The t(12;21) translocation that generates the ETV6-RUNX1 ( TEL-AML1 ) fusion gene, is the most common chromosomal rearrangement in childhood cancer and is exclusively associated wit...
ObjectiveTo investigate the clinical significance of monitoring ETV6-RUNX1 fusion gene in children with acute lymphoblastic leukemia (ALL) after allogeneic stem cell transplantation (allo-HSCT) . MethodsClinical data of 13 children received allo-HSCT in Peking University Institute of Hematology from May...
TEL-AML1 (ETV6-RUNX1) fusions are common (∼25%) in paediatric B cell precursor acute lymphoblastic leukaemia (ALL) and associated with a very favourable prognosis. Our prior studies on monozygotic twins with concordant ALL and ‘backtracking’ studies using archived neonatal blood spots establish...
This leukaemia appears to derive from a B-cell progenitor rather than a haematopoietic stem cell. 【翻译】这类白血病似乎起源于祖B细胞,而不是造血干细胞。 The ETV6-RUNX1 translocation results in the production of a...
The TEL-AML1 fusion gene usually arises before birth, producing a persistent and covert preleukemic clone that may convert to precursor B cell leukemia following the accumulation of secondary genetic "hits." Here, we show that TEL-AML1 can induce persistent self-renewing pro-B cells in mice....
(syn.: ETV6-RUNX1) expression leads to expansion of B-cell precursors with enhanced self-renewal capacity and impaired differentiation to more mature B-cell stages.3–8 The translocation already occurs in utero in an early B-cell progenitor cell and leads to establishment of a pre-leukemic ...