Next generation sequencing of diagnosis samples unexpectedly detected both ETV6::ABL1 type A and B fusion transcripts, which were then confirmed by FISH. The diagnosis was Myeloid/Lymphoid neoplasm with ETV6::ABL1 fusion, and the patient received imatinib mesylate treatment. In ...
首先可以通过COSMIC网站查找ETV6-ABL1常见的融合为点，如下图所示：从查询结果来看常见的融合为COSF2362、...
30, No. 8儿童ETV6⁃ABL1融合基因阳性急性淋巴细胞白血病一例并文献复习马海欢1常海岩1毛翠1郭祥意1贾晓冬1陈建春1王玥21 天津金域医学检验实验室有限公司细胞遗传室300392;2 厦门大学附属第一医院儿科,福建 厦门 361003通信作者:马海欢,Email:342462964@qq.com【摘要】 目的 探讨ETV6⁃ABL1融合基因阳性急性淋巴...
ETV6-ABL1融合基因阳性的急性淋巴细胞白血病(ALL)是一种罕见的白血病,临床病例很少,报道的26例病例中,急性髓系白血病(AML)3例,B-ALL 8例,T-ALL 1例,难治性贫血伴原始细胞增多(RAEB)转AML 1例,慢性骨髓增殖性肿瘤2例,费城染色体阴性的CML 11例,年龄从8个月至81岁不等。嗜酸性粒细胞增多似乎是与ETV6-ABL1...
第35天复查微小残留病(MRD)转阴;荧光定量聚合酶链反应检测证实ETV6-ABL1融合基因阳性;流式细胞术结果符合急性B淋巴细胞白血病/淋巴母细胞淋巴瘤免疫表型;荧光原位杂交检测示,67%间期细胞显示了1个额外的ABL1信号.结论ETV6-ABL1融合基因阳性ALL罕见,具有独特的实验室及临床特征,为此类疾病常规细胞遗传学的异质性提供了...
It was ultimately found to have complex translocations involving chromosomes 6, 9 and 12 which resulted in an ETV6-ABL1 fusion gene. Method: Following the unexpected negative FISH and molecular results for the BCR-ABL1 fusion gene, further investigations were undertaken. These included conventional ...
Biomarker Research (2016) 4:16 DOI 10.1186/s40364-016-0070-7 SHORT REPORT Open Access A novel three-way rearrangement involving ETV6 (12p13) and ABL1 (9q34) with an unknown partner on 3p25 resulting in a possible ETV6-ABL1 fusion in a patient with acute myeloid leukemia: a case ...
[BCR/ABL(ES)]/[ETV6/RUNX1]/KMT2A/[CDKN2A/CSP9]探针-探针-广州安必平医药科技股份有限公司(股票代码:688393)专注于肿瘤筛查与诊断,自主研发了一系列肿瘤筛查及诊断试剂与配套设备,主要应用科室为病理科。目前已搭建液基细胞学(LBP)、聚合酶链式反应(PCR)、免疫组
[BCR/ABL(ES)]/[ETV6/RUNX1]/KMT2A/[CDKN2A/CSP9]探针-探针-广州安必平医药科技股份有限公司(股票代码:688393)专注于肿瘤筛查与诊断,自主研发了一系列肿瘤筛查及诊断试剂与配套设备,主要应用科室为病理科。目前已搭建液基细胞学(LBP)、聚合酶链式反应(PCR)、免疫组
首先可以通过COSMIC网站查找ETV6-ABL1常见的融合为点，如下图所示：从查询结果来看常见的融合为COSF2362、...