本次发现的ETV6::ACSL6基因融合为罕见融合,根据已有病例报道,ETV6::ACSL6融合可见于慢性嗜酸性粒细胞白血病(CEL)、骨髓增殖性肿瘤(MPN)、骨髓增生异常综合征/骨髓增殖性肿瘤(MDS/MPN)和急性髓系白血病(AML)等;虽然ETV6::ACSL6基因...
Conclusions: Patients with the ETV6-ACSL6 fusion gene mainly present with myeloproliferative and myelodysplastic disorders, typically with increased eosinophils and/or basophils and poor survival. Intensive therapies such as allogenic stem cell transplantation should be an initial consideration for eligible ...
Almost 10 years ago, six cases of t(5;12)(q23-31;p13) with ETV6-ACSL6 gene fusion were summarized in Leukemia, including acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute eosinophilic leukemia (AEL) and polycythemia vera (PV) [7]. Here, we report a case of t(5;...
t(5;12)(q23-31;p13) with ETV6-ACSL6 gene fusion in polycythemia vera. Leukemia. England, v. 20, n. 6, p. 1175-1178, June 2006.Murati A, Adelaide J, Gelsi-Boyer V, Etienne A, Remy V, Fezoui H, Sainty D, Xerri L, Vey N, Olschwang S, Birnbaum D, Chaffanet M, Mozz...
t(5;12)(q31;p13)/ ETV6::ACSL6 and t(6;9)(p23;q34)/ DEK::NUP214 concurrence in acute myeloid leukemia: an unusual association of two rare abnormalitiesCarmen Baldazzi aSimona Luatti aGiulia Marzocchi bAlessandra Grassi aMichele Cavo a b...