Epigenetics广义的来说是指genome不发生变化,但phenome却发生了改变,而这种改变是可遗传的。一般这种改变,来源于外界环境因素的影响,在methylation,RNAi,Histone Acetylation的机制下对于基因表达进行调整。例如营养因素导致蜂后和工蜂的差异。个人觉得在目前全球气候变化的情况下,epigenetics的研究对于植物还是有重要意义的。例...
DNA methylation and histone acetylation have also been implicated in the modulation of basal synaptic transmission and the balance between excitation and ... ED Nelson,LM Monteggia - 《Neurobiology of Learning & Memory》 被引量: 98发表: 2011年 Prognostic role of global DNA-methylation and histone...
HighlightsDNA and histone methylation and histone acetylation are key mechanisms involved in epigenetic regulation of cancer, viral latency and transgenerational inheritance.These covalent modifications of chromatin are managed by several families of protein complexes known as writers, erasers and readers....
Site-Specific Analysis of Histone Methylation and Acetylation David Umlauf, Yuji Goto, Robert Feil Pages 99-120 Analysis of Mammalian Telomere Position Effect Joseph A. Baur, Woodring E. Wright, Jerry W. Shay Pages 121-136 Activity Assays for Poly-ADP Ribose Polymerase ...
In epigenetics, formylation of histone lysine residues enhances DNA binding and blocks methylation and acetylation. FRET (Fö rster An extremely sensitive technique to measure resonance energy distances between molecules using light transfer) sensitive chromophores。 Glycosylation The chemical linkage of a...
effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation....
These modifications, chiefly on the arginine and lysine residues in histone tails, are vital for the epigenetic regulation of gene expression (Smith and Denu, 2009). Acetylation and methylation of histones are among histone modifications that play an important role in the epigenetic regulation of ...
(such as histone methylation, acetylation and lactylation), chromatin remodeling and epitranscriptomic modifications (such as N6-methyladenosine modification, m6A). These modifications primarily rely on the coordinated action of "writer," "reader," and "eraser" enzymes (Additional file 1: Table S1),...
Various post-translational modifications, such as acetylation, methylation, phosphorylation, ubiquitination, phase polymerization, and ADP ribosylation, occur at the tail or acid pocket of histones, particularly of H3 and H4, which regulate gene expression by altering chromatin accessibility. The modulating...
Manytumoursandcancersinvolve epigenetic changes attributable toenvironmentalfactors. These changes include a general decrease in methylation, which is thought to contribute to the increased expression of growth-promoting genes, punctuated by gene-specific increases in methylation that are thought to silencetum...