The activation of p53 and its turnover are important components of the cell-cycle regulatory mechanism. Histone acetylation dynamics is involved in both these components. The important role that histone acetyl transferase (HAC) and histone deacetylases (HDAC) play in controlling the expression of ...
mainly associated with increased methylation in the junglefowl genotype. In a third of eQTL, we find that there is a correlation between gene expression and methylation, while statistical causality analysis reveals multiple instances where methylation is driving gene expression, as well as the reverse...
Methylation will also block other types of modifications, such as acetylation and ubiquitination, at a given lysine. Lysine methylation has been studied extensively in the context of histones and chromatin biology. Histone methylation contributes to the regulation of gene expression, particularly through ...
DNA methylation, a key epigenetic modification, typically involves the addition of a methyl group to the fifth carbon of cytosine to produce 5-methylcytosine (5mC) in eukaryotic genomes [9,10]. Although the relationship between DNA methylation and its effect on gene expression is complex [11,12...
tRNA is the RNA type that undergoes the most modifications among known RNA, and in recent years, tRNA methylation has emerged as a crucial process in regulating gene translation. Dysregulation of tRNA abundance occurs in cancer cells, along with increased expression and activity of tRNA methyltransfe...
In this work, we analyzed 3 different histone epigenetic marks: dimethylation of H3K9 (H3K9me2) and acetylation of H3 and H4 (H3Ac and H4Ac) during microspore embryogenesis in Brassica napus by Western blot and immunofluorescence assays. The expression patterns of histone methyltransferase BnHKMT ...
SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development. J Anim Sci Biotech. 2017;8:83. Article Google Scholar Kageyama S-i, Liu H, Kaneko N, Ooga M, Nagata M, Aoki F. Alterations in ...
ddm1 mutations would lead to a loss of chromatin identity, creating an unrecognizable/unmethylatable template for the DNMTase. Under the "chromatin identity" model, ddm1 mutations compromise a determinate of chromatin structure, such as histone acetylation state, and the loss of methylation is a ...
Chapter 4 Role of histones and their acetylation in control of gene expression It has been established over a number of years that histone acetylation is correlated with the transcriptional state of chromatin. Recent experiments have begun to analyze this correlation in more detail and have establishe...
[0050] Meanwhile, a histone deacetylase inhibitor inhibits deacetylase of the histones in the nucleosomal core of the gene, thus resulting in net increase of the acetylation of histones, which, in turn, activates transcription of the gene. By exploiting these two complementary mechanisms, the combin...