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In this scenario, these pathways sense and integrate nutrient signals for the induction of coordinated gene expression programs in cancer. This...doi:10.1038/nrm.2017.61ZlotorynskiEytanNat Rev Mol Cell BiolNature Reviews Molecular Cell Biology
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell 153, 1448–1460 (2013). Article PubMed PubMed Central CAS Google Scholar Asher, G. et al. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134, 317–328 (2008)...
Acetylation of lysine residues in histone proteins can control the secondary structure of chromatin as well as gene expression levels from certain loci, and chromatin remodeling and its consequences in a variety of molecular and cell biological questions are intensely researched. Many other proteins ...
Histone acetylation regulates gene expression. Whether this is caused by a general increase in nucleosome fluidity due to charge neutralization or by a more specific code is still matter of debate. By using a set of glucose-repressed Adr1-dependent genes of Saccharomyces cerevisiae , whose transcrip...
N-terminal tails of H2A, H2B, H3 and H4 histone families are subjected to posttranslational modifications that take part in transcriptional regulation mechanisms, such as transcription factor binding and gene expression. Regulation mechanisms under control of histone modification are important but remain ...
4-D). Metadata analysis of RNA-seq results at global and gene levels aimed at comparing the TSA- and auxin-induced transcriptomic changes and indicating candidate genes of Hac-regulated expression in SE induction. The candidate genes included theTFgenes of the master regulatory function in SE, ...
Cre gene expression was also examined by PCR. All mice were maintained and bred at the Division of Laboratory Animal Resources at East Tennessee State University (ETSU). All experimental procedures were performed in accordance with the Guide for the Care and Use of Laboratory Animals published by...
Genomic Analyses of Transcription Factor Binding, Histone Acetylation, and Gene Expression Reveal Mechanistically Distinct Classes of Estrogen-Regulated Pr... 2007. Genomic analyses of transcription factor binding, histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-...
changes in gene expression may be small and distributed across many genes. However, similar to previous studies, more powerful enrichment analyses in the limma package were used. These evaluate enrichment based on genes that are not necessarily genome-wide significant and identify sets of genes for...