DNA methylation in mollusks One of the most studied epigenetic bearers of information is DNA methylation, which involves the biochemical modification of a DNA base. In animals, cytosine methylation most often occurs in a CpG dinucleotide context and is catalyzed by DNA methyltransferases (DNMTs) whic...
Epigenetic changes may fill a critical gap in our understanding of kidney disease development, as they not only reflect metabolic changes but are also preserved and transmitted during cell division. We conducted a genome-wide cytosine methylation analysi
We then thought to evaluate if the homogeneous epigenetic fraction of the sperm genome that is transmitted to the embryo contributes to the regulation of embryonic gene expression. We first compared early embryonic expression of genes with heterogenous methylation in sperm to that of genes that have...
One common strategy observed in several trials involves knocking out the PD1 gene, which encodes for the programmed cell death protein 1. PD1 is known to be involved in inhibiting T cell activity, and by removing it, the modified T cells, known as autologous TILs and autologous EBV-specific ...
ZEB2 shapes the epigenetic landscape of atherosclerosis. Circulation. 2022;145(6):469–85. Article CAS PubMed PubMed Central Google Scholar Goh WWB, Wang W, Wong L. Why batch effects matter in omics data, and how to avoid them. Trends Biotechnol. 2017;35(6):498–507. Article CAS Pub...
while methylation in the gene body promotes gene expression, as reported in most cancers including HCC [108]. Among the DNMTs, DNMT1 is essential for the maintenance of methylation pattern in the genome, by regulating gene expression but also other epigenetic regulators (e.g. miRNAs) in HCC ...
DNA methylation, one of the epigenetic modifications, can regulate pyroptosis of tumor cells. Studies have shown that DNA methylation mediates the down-regulation of ZDHHC1 in cancer. Up-regulation of ZDHHC1 can alter cellular metabolism and induce oxidative stress-mediated pyroptosis to inhibit tumor...
DNA methylation, a key epigenetic modification, typically involves the addition of a methyl group to the fifth carbon of cytosine to produce 5-methylcytosine (5mC) in eukaryotic genomes [9,10]. Although the relationship between DNA methylation and its effect on gene expression is complex [11,12...
DNA methylation (DNAm) has been implicated in acute coronary syndrome (ACS), but the causality remains unclear in cross-sectional studies. Here, we conduct a prospective epigenome-wide association study of incident ACS in two Chinese cohorts (discovery:
The mechanisms that are universally attributed to the effects of diet on disease and health are mainly classified into two types (Table2; Fig.2): (1) nutrient-mediated mechanisms, covering metabolic regulators, nutritive metabolism pathways, epigenetic mechanisms and circadian clocks; and (2) diet...