Methylation, a key epigenetic modification, is essential for regulating gene expression and protein function without altering the DNA sequence, contributing to various biological processes, including gene transcription, embryonic development, and cellular functions. Methylation encompasses DNA met...
Epigenetic modification, which involve DNA methylation, RNA-associated silencing and histone modification, is implicated in cell proliferation,differentiation, survival, apoptosis and malignant transformation. Some leukemogenesis has been shown to be aberrance of epigenetic modification. This paper discussed the...
Demethylation and epigenetic modification with 5-Azacytidine reduces IDH1 mutant glioma growth in combination with Temozolomide5-azacytidine... YA Shimura,CRM Da,B Alexandra,... - Neuro-Oncology 被引量: 0发表: 2018年 IDH mutations predict longer survival and response to temozolomide in secondary glio...
Cancer, after cardiovascular disease, is ranked as the second leading cause of death worldwide [1]. Approximately twenty million new cancer cases were diagnosed in 2020. Lung, prostate, liver, colorectal, and stomach cancers are the most common cancers among men, while breast, colorectal, thyroid...
Epigenome-modifying enzymes, which use substrates such as acetyl and methyl groups for post-translational modification of histones or DNA, are highly sensitive to fluctuations in metabolite levels22,23,24. Several studies already explored epigenetic changes in patients with kidney disease. Cytosine ...
Epigenomes including genome-wide histone modification and DNA methylation profiles are important for genome activity and for defining gene expression patterns of plant development and responses to various environmental conditions. Rice is the most important crop plant and serves as a model for cereal gen...
www.antpedia.com|基于60个网页 2. 强化基因外修饰 ...尔表示,处於压力状态下会分泌皮质醇和肾上腺素,因此强化基因外修饰(epigenetic modification) 机制,改变脑部神经元内 … mypaper.pchome.com.tw|基于20个网页 3. 表观遗传修改 ...已经被揭开,暗箱操作的秘密也慢慢为我们所知,这就是表观遗传修改(Epigene...
37, 38, 39, 40 The crosstalk between DNA methylation and histone modification suggests that histone modifications, such as H3K9me, initiate heterochromatin formation and subsequent DNA methylation ensures stable silencing of the promoter.15 DNA methylation analysis technologies The three main principles ...
Cancer epigenomics: DNA methylomes and histone-modification maps. Nat. Rev. Genet. 8, 286–298 (2007). CAS PubMed Google Scholar Straussman, R. et al. Developmental programming of CpG island methylation profiles in the human genome. Nat. Struct. Mol. Biol. 16, 564–571 (2009). CAS ...
Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet 10: 295–304. Neuropsychopharmacology Chertkow-Deutsher Y, Cohen H, Klein E, Ben-Shachar D (2010). DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-...