Epigenetics and MicroRNAs in Cancer. Int J Mol Sci, 2018 , 19(2): 459Wise, P. M., Challagundla, K., and Fabbri, M. (2015). Epigenetics and microRNAs in cancer. In Rezaei, N. (ed.), Cancer Immunology: A Translational Medical Context , Springer, New York, pp. 285–294....
MicroRNAs (miRNAs), a class of endogenous, single-stranded, non-coding small RNA with 18鈥 22 nucleotides in length, play a critical role in initiation, progression, metastasis and invasion of cancers. It is widely recognized that deregulation of miRNAs is a hallmark of cancer. The expression ...
W., Hardy, T. M., and Tollefsbol, T. O. (2013). MicroRNAs: an emerging science in cancer epigenetics. J. Clin. Bioinforma. 3:6. doi: 10.1186/2043-9113-3-6Kala R,Peek GW,Hardy TM. MicroRNAs:an emerging science in cancer epigenetics[J].J Clin Bioinforma,2013,(01):6-11....
The emergence of nanotechnology applied to medicine has revolutionized the treatment of human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs have evolved in terms of their specificity and efficiency, especially because of the possibility of using more effective ...
Recurrence rates after breast-conserving therapy may depend on genomic characteristics of cancer-adjacent, benign-appearing tissue. Studies have not evaluated recurrence in association with multiple genomic characteristics of cancer-adjacent breast tissu
5, Pt 2, 2007 Printed in U.S.A. Epigenetics and MicroRNAs JODY C. CHUANG, AND PETER A. JONES Department of Biochemistry and Molecular Biology [J.C.C., P.A.J.], Department of Urology [P.A.J.], USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, ...
Epigenetics and miRNAs in human cancer. Epigenetic factors and microRNAs (miRNAs) are regulators of gene expression. Their regulatory function is frequently aberrant in . In this chapter, we show that a tight connection occurs between miRNAs and epigenetics. Epigenetic factors... M Fabbri,GA Calin...
miRNA SNPs and Cancer: What a Difference a Base Makes July 15, 2011 In the past decade, scientists have realized that small, non–protein-coding RNAs can substantially alter gene expression. MicroRNAs (miRNAs) block the translation of their mRNA targets, usually by binding to complementary sequen...
In the past few years, the roles of epigenetics in cancer have been fully accepted. Recently, there has been an increased focus on epigenetic alterations underlying esophageal cancer carcinogenesis, with several epigenetic drug and RNA interference therapies being tested. However, the conclusion that ...
and genesis of the resident miRNA. It is therefore reasonable to deduce that epigenetic changes brought on by transformation can potentially affect miRNA expression in both direct and indirect ways. We have reviewed the literature pertaining to the epigenetic regulation of miRNA genes in the context ...