As any other malignancies there are three main aspects in the management of breast cancer: diagnosis (early detection is crucial), tumor classification/prognosis and treatment. This chapter focuses on the practical roles of epigenetic alterations (mainly DNA methylation) in these three clinical ...
Epigenetics and Breast Cancerrepeats, are silenced in somatic cells and become reactivated in human cancer (Berdasco & Esteller, 2010). Furthermore, aberrations in DNA methylation patterns of the CpG islands in the promoter regions of tumor-suppressor genes are accepted as being a common feature ...
In this chapter, we review the central roles that epigenetic mechanisms, including DNA methylation, histone posttranslational modifications, and nucleosome positioning, play in governing gene expression and how their dysregulation contributes to carcinog
Moreover, it highlights the current limitations and obstacles associated with applying these experimental strategies in the clinics. Keywords: epigenetics; breast cancer; nanomedicine; epi-drugs; targeted delivery; drug resistance Graphical Abstract 1. Introduction The most common cancer diagnosed among ...
Androgen receptor (AR) signaling is the central signal transduction pathway in prostate cancer. Many different epigenetic mechanisms affecting this critical pathway play a role in disease initiation and progression. This includes the presence of AR variants that are constitutively transcriptionally active, ...
Breast cancer (BC) presents persistent challenges due to subtype-specific limited efficacy and potential resistance to standard therapy, influenced by the dynamic reversible nature of epigenetic plasticity. This study aims to comprehensively explore the evolving BC epigenetic landscape, analyzing trends and...
Development of human cancer can proceed through the accumulation of different genetic changes affecting the structure and function of the genome. Combined analyses of molecular data at multiple levels, such as DNA copy-number alteration, mRNA and miRNA expression, can clarify biological functions and ...
Epigenetics of breast cancer: Modifying role of environmental and bioactive food compounds Scope Reduced expression of tumor suppressor genes (TSG) increases the susceptibility to breast cancer. However, only a small percentage of breast tumors i... DF Romagnolo,KD Daniels,JT Grunwald,... - 《Mole...
Evidence of accelerated epigenetic aging of breast tissues in patients with breast cancer is driven by CpGs associated with polycomb-related genes Age is one of the strongest risk factors for the development of breast cancer, however, the underlying etiology linking age and breast cancer remains un...
While the role of epigenetics in several solid tumor cancers such as colorectal cancer are well established, there is emerging evidence that epigenetics also plays a critical role in breast and prostate cancer. In breast cancer, DNA methylation profiles have been linked to hormone receptor status ...