Structure and function integrated Enzyme structure and mechanism: by Alan Fersht, W. H. Freeman and Co., Reading and San Francisco, CA, 1977. $9.95 (xvii + 371 pages) ISBN 0 7167 0189 8Guidelines for submitting commentsPolicy: Comments that contribute to the discussion of the article will ...
Changes in the structure of tropomyosin (TM) altered the texture profiles of eel balls and the inhibitory activity of the angiotensin-converting enzyme (AC... Zhenglong,Li,Huipeng,... - 《Food & Function》 被引量: 0发表: 2018年 Structure-inhibition relationship of phenylethanoid glycosides on ...
Inhibition of Insulin Degrading Enzyme to Control Diabetes Mellitus and its Applications on some Other Chronic Disease: a Critical Review This review aims to provide a precise perceptive of the insulin-degrading enzyme (IDE) and its relationship to type 2 diabetes (T2D), Alzheimer's disease (.....
Traditionally, four types of restriction enzymes are recognized, designated I, II, III, and IV, which differ primarily in structure, cleavage site, specificity, and cofactors. Types I and III enzymes are similar in that both restriction and methylase activities are carried out by one large enzyme...
One differential inhibition of cell-cycle progression and of the appearance of an enzymatic activity is already known (Oleinick, 1972). There may be other periods in the mitotic cycle when radiation could delay the “triggering mechanism” for the periodic synthesis of an enzyme as well as ...
The specific activity of enzymes can be altered over long timescales in cells by synonymous mutations that alter a messenger RNA molecule’s sequence but not the encoded protein’s primary structure. How this happens at the molecular level is unknown. He
Crystal Structure of T4 Endonuclease V: An Excision Repair Enzyme for a Pyrimidine Dimer The x-ray structure of T4 endonuclease V, an enzyme responsible for the first step of a pyrimidine-dimer-specific excision-repair pathway, was determined a... K Morikawa,M Ariyoshi,D Vassylyev,... - ...
Structure and function of ubiquitin conjugating enzyme E2-25K: The tail is a core-dependent... Investigates the structure and function of ubiquitin conjugating enzyme. Mediation in the ubiquitination process; Substrates in the ubiquitin-dependent deg... Haldeman,Margaret,T.,... - 《Biochemistry》 ...
In this study, we report the crystal structure of 17β-HSD5 in complex with a potent inhibitor EM1404 and another structure with a segment of polyethylene glycol (PEG) made from 6 ethylene glycol units (C12H25O6) bound in the active site. Enzyme inhibition by EM1404 was also studied, ...
we solved the crystal structure of theStreptomyces coelicolorFGE homolog to 2.1Å resolution. The prokaryotic homolog exhibits remarkable structural similarity to human FGE, including the position of catalytic cysteine residues. Both biochemical and structural data indicate the presence of an oxidized cyst...