Stein RL. Kinetics of enzyme action: essential principles for drug hunters: John Wiley & Sons; 2011.R.L. Stein, Kinetics of enzyme action: Essential principles for drug hunters, Wiley, Hoboken, 2011.Stein, RL. Kinetics of Enzyme Action: Essential Principles for Drug Hunters. Wiley; New York...
administration of hepatotoxic agents, which causes either an increase in the rate of enzyme degradation (eg, carbon tetrachloride and carbon disulfide) or a decrease in the rate of enzyme synthesis (eg, puromycin and dactinomycin). Enzyme inhibition may also produce undesirable xenobiotic interactions...
Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 37, Issue 1 (2022)See all volumes and issues Share Vol 40, 2025 Vol 39, 2024 Vol 38, 2023 Volume 37, 2022 Vol 36, 2021 Vol 35, 2020 Vol 34, 2019 Vol 33, 2018 Vol 32, 2017 Vol 31, 2016 Vol 30, 2015 Vol 29, ...
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Enzyme inhibition is a reaction between a molecule and an enzyme that blocks the action of the enzyme, either temporarily or...
A mechanism of action for Panax ginseng (PG) and Eleutherococcus senticosus (ES) is proposed which explains how they could produce the paradoxical effect of sometimes increasing and sometimes decreasing the stress response. The mechanism suggests that this biphasic effect results from increased occupancy...
of these enzymes may result in a modification of drug action. A wide range of chemically unrelated substances may stimulate the activity of the mixedfunction oxidases by enzyme induction. The drugs most frequently encountered as enzymeinducing agents in man are barbiturates, rifampicin and Phenytoin...
Activation of tumor-intrinsic innate immunity has been a major strategy for improving immunotherapy. Previously, we reported an autophagy-promoting function of the deubiquitinating enzyme TRABID. Here, we identify a critical role of TRABID in suppressing anti-tumor immunity. Mechanistically, TRABID is...
Notably, USP5 was mainly found in the nuclei of cells co- transfected with c-Maf (Figures 1e and f). Therefore, USP5 interacted with c-Maf and its cellular distribution was affected by c-Maf. Because USP5 is a putative enzyme to prevent protein ubiquitination,12 we wondered whether USP...
FAO is initiated by the conversion of the long-chain fatty acids into fatty acyl-CoAs by the action of ACSL1 enzyme followed by transport into the inner mitochondrial membrane through the activity of carnitine palmitoyl transferases, CPT1 and CPT2. In the mitochondria, FAO is characterized by...