Enzyme inhibition is a reaction between a molecule and an enzyme that blocks the action of the enzyme, either temporarily or permanently, depending on the type of enzyme inhibitor involved. This process occurs in the natural world all the time, and it has a number of applications for humans,...
Stein RL. Kinetics of enzyme action: essential principles for drug hunters: John Wiley & Sons; 2011.R.L. Stein, Kinetics of enzyme action: Essential principles for drug hunters, Wiley, Hoboken, 2011.Stein, RL. Kinetics of Enzyme Action: Essential Principles for Drug Hunters. Wiley; New York...
This typically occurs through the action of kinase enzymes, which can either inhibit or activate an enzyme depending on the situation. The kinase enzymes cleave off a phosphate group from ATP and bind it to the enzyme. In situations where this results in an increase in enzyme activity it ...
administration of hepatotoxic agents, which causes either an increase in the rate of enzyme degradation (eg, carbon tetrachloride and carbon disulfide) or a decrease in the rate of enzyme synthesis (eg, puromycin and dactinomycin). Enzyme inhibition may also produce undesirable xenobiotic interactions...
Kinetics of Enzyme Action: Essential Principles for Drug Hunters Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the... RL Stein - John Wiley...
The Fe-S clusters of the mitochondrial outer membrane are destroyed by lipoxygenase treatment, without any effect on the rotenone-insensitive NADH : cytochrome c oxidoreductase activity. It is concluded that these clusters are not involved in this enzyme. 展开 ...
The latter complex is assumed to be the transition state in the enzyme-catalyzed reaction. If the theory is correct, it opens up the possibility of studying intermediates and transition states from the known structures of chemical inhibitors. 展开 ...
The plots after inhibition do not appear to be analogous to any of the known forms of competitive, uncompetitive or non-competitive inhibition of enzyme kinetics. Rather a "mixed-type" of inhibition is suggested, combining the attributes of competitive and non-competitive inhibition. 展开 ...
Angiotensin-converting enzyme (ACE) inhibitors have been designed to reduce the generation of angiotensin II, i.e., to block the renin-angiotensin system. Interestingly, there exists a considerable dissociation between the time course of ACE inhibition and that of blockade of the renin-angiotensin ...
“flap” covering the dinickel centre of the enzyme, which consequently locks the flap in a specific conformation leading to the loss of catalytic activity. The third category of compounds consists of metal ion chelators, such as EDTA, which can sequester Ni2+, inhibiting the formation of the...