Enzyme inhibition therapy uses specific molecules to inhibit enzyme activity, targeting disease-related enzymes in medical treatments like cancer treatment and infectious disease management. Different types of inhibitors, competitive and non-competitive, bind to different sites and alter enzyme function. The...
The objective of this study was to investigate whether the acute haemodynamic effects of angiotensin-converting enzyme inhibition with captopril could be enhanced by oestrogen administration, and then to evaluate the mechanisms involved ... José,Giménez,M.,... - 《Experimental Physiology》 被引量:...
In our work, we present a relation between the influence of immobilization on the improvement of the properties of selected oxidoreductases and their commercial value. We also present our view on the role that different immobilization methods play in the reduction of enzyme inhibition during ...
- 《Journal of Enzyme Inhibition》 被引量: 23发表: 1998年 S-adenosyl-L-methionine production by an ergosterol-deficient mutant of Scheffersomyces stipitis S-adenosyl-L-methionine (SAM, SAMe; AdoMet) is an important methyl donor in many reactions, and recently has attracted much attention due ...
Advancements in genetic engineering have profoundly impacted the biotherapeutic industry and shaped many of the methods and strategies used today for both
the determination of which enzymes and compositions will be most effective in converting biomass into simple sugars is a challenge, and computational methods were used to determine the optimal composition. Some of these computational methods include predicting the tertiary structure of enzyme and analyzing...
Gene variation in resistant hypertension: multilocus analysis of the angiotensin 1-converting enzyme, angiotensinogen, and endothelial nitric oxide synthase genes. DNA Cell Biol. 2011;30:555–64. Article CAS PubMed Google Scholar Laffer CL, Elijovich F, Eckert GJ, Tu W, Pratt JH, Brown NJ. ...
A microtiter plate-based enzyme immunoassay has been developed for phaseolinone, a phytotoxin isolated from the culture filtrate of the plant-pathogenic fungus Macrophomina phaseolina (Tassi) Goid. The smallest amount of phaseolinone detectable by the method is 5 pg per well. The method is valida...
(II) complex was used as a small molecule enzyme mimic for miRNA signal while Fe3O4were used as a separate target under magnetic field and was able to detect miRNA sensors. This method is expected to become a scheme to study next generation microRNA sensors, without the need of enzyme ...
The FA-MLR describes the effect of geometrical and quantum indices on enzyme inhibition activity of the studied molecules. The quality of PCRA equation was found to be better than those derived from FA-MLR. GA-PLS analysis indicated that the topological (IC4 and MPC06), constitutional (nf) ...