Guo F, Liu X, Qing Q, Sang Y, Feng C, Li X, et al. EML4-ALK induces epithelial-to-mesenchymal transition consistent with cancer stem cell properties in H1299 non-small cell lung cancer cells. Biochem. Biophys. Res. Commun. 459: 398-404, 2015....
EML4–ALK proteins are highly transforming and pathogenic in NSCLC due to increased oligomerization and constitutive, kinase-activating autophosphorylation: through activation of several downstream signaling pathways such as RAS/MAP kinase and PI3K/AKT, they lead to cell proliferation and de-differentiation...