Previous work based on untargeted liquid chromatography identified 30 differential metabolites of CRC. Among them, only beta-hydroxybutyrate (BHB) was elevated in CRC. Here, we first confirm the increased level of beta-hydroxybutyrate by targeted metabolomic analysis using an independent cohort of 400 ...
In line with these findings, functional validation demonstrated increased levels of two key ketone bodies, acetoacetate and beta-hydroxybutyrate, in the SLC13A5-KD cells. Additional experiments showed that SLC13A5-KD sensitizes HepG2 cells to cellular stress caused by a number of chemotherapeutic ...