Electric field regulated signaling pathways. Int. J. Biochem. Cell Biol. 55, 264–268 (2014). Article CAS PubMed Google Scholar Grimnes, S. & Martinsen, Ø. Bioimpedance and Bioelectricity Basics: Third Edition (2014). Hanemaaijer, R. et al. Inhibition of MMP synthesis by doxycycline ...
evidenced by the upregulated gene expression of collagen type I (COL I) and downregulated gene expression of Sox9, collagen type II (COL II) and aggrecan (AGG) with activation of the wnt/β-catenin signaling pathway. Inhibition of the wnt/β-catenin pathway partially blocked these effects. Th...
Some genes correlated with cell migration, such as Serpine1, Ctgf, Fosb , and Fos , were upregulated. The signaling pathways involved in cell motility were significantly altered. Some genes, highly related to tumorigenesis, invasion, and metastasis, are upregulated in response to EF stimulation....
Electrophoretic redistribution of cell surface receptors likely governs the galvanotropic response of neurons to a horizontally oriented two-dimensional applied field (Patel and Poo, 1982). Such mechanisms do not fully explain altered cell function in response to stimulation applied to the substrate or ...
The development of new biomaterials and medical devices has become a growing field of interdisciplinary research. The medical devices for tissue and cell t
We then explored the involved intracellular signaling mechanism of the EF boosted neuronal differentiation of NSCs. According to protein expression and phosphorylation detection by immunoblotting, the p-PI3K/PI3K ratio was significantly increased by EF stimulation, demonstrating an up-regulated PI3K activati...
Numerous cellular signalling pathways have been regulated under electric field (EF) stimulation. Various membrane receptors6,7,8,9,10or ion channels11,12,13,14,15have been suggested to act as EF sensors and initiate many intracellular signalling cascades in different cell types8,13,16,17,18,19...
To address the role of RboH, we used the specific inhibitor diphenylene iodonium (DPI) and found that all three biosynthetic genes were upregulated, no matter, whether the respective gene product was localised in the plastid or not (indicating that retrograde signaling is not relevant for this ...
We sought to elucidate which signaling pathways were used to modulate the innate immune response to bacterial infection. Since IVM was one of the most potent inducers of increased resistance to infection we identified, we focused our investigation on the downstream intracellular mediators of its effect...
The theory is that a heightened electrical field strength occurs where the currents from each of the electrode pairs cross, which stimulates nerves in that area156. One particular advantage of TIENS over other nerve stimulation procedures is that it is non-invasive. The method has been most comm...