Immunohistochemical detection of EGFR expression in normal and iUC canine tissues.Deepika, Dhawan
which was consistent with the results of protein level determination.Conclusion There is no expression of EGFR in normal tissues and neural stem cells.But high expression of EGFR is observed in tumor,specifically in brain tumor stem cells.The expression of EGFR is related closely to malignant ...
In head and neck squamous cell carcinoma (HNSCC), expression levels of the epidermal growth factor receptor (EGFR) correlate with poor prognosis and decreased survival rates. As the mechanisms responsible for cellular immune response to EGFR in vivo rema
These are impressively wide predicted safety margins in a relevant toxicology species, with HER2 having more potential given a more limited expression profile in normal tissues versus EGFR. Clinical studies are needed to understand whether these safety margins are adequate for HER2 and EGFR. XPAT ...
Moreover, DPBA does not alter EGFR expression in normal human cells. DPBA potently inhibits the growth of several EGFR-positive NSCLC xenografts and has negligible toxicity. Overall, DPBA is a novel EGFR degrader that could potentially treat both EGFR WT and EGFR mutant NSCLC. EGFR ICD ...
A significantly higher expression of EGFR and EGFRvIII was observed in tumors as compared to normal tissues. Moreover, the expression of EGFR and EGFRvIII in esophageal carcinoma was significantly associated with the tumor location and degree of tumor invasion, tumor-node- metastasis (TNM) staging,...
Expression of c-erbB-2 protein and epidermal growth factor receptor in normal tissues of the female genital tract and in the placenta Thus, there is an inverse relationship between the expression of c- erb B-2 protein and EGFR in the tissues of the female genital tract and in the ... Da...
The normal brain tissues served as a control. Results The expression of NF-κB was not detected in 8 specimens of normal brain tissues. The positive rate of NF-κB protein expression was 67.9% in the gliomas. The positive rate of NF-κB expression in the high grade glioma was significantly...
Considering our previous findings that PELI1 showed higher expression in breast cancer than adjacent tissues, we examined whether PELI1 is commonly abundant in other cancers by a multiple tumor tissue microarray assay, including colon cancer, lung cancer, rectum cancer, breast cancer and prostate ca...
To investigate the expression of GRHL1 in NSCLC, we first analyzed the expression of GRHL1 in NSCLC samples in TCGA. The results showed that the mRNA level of GRHL1 is significantly higher in tumor tissues than in normal tissues (Fig.1A). The relationship between GRHL1 expression and patient...