Glomerular Filtration Rate (GFR): What to Know Medically reviewed by Jabeen Begum on March 12, 2024 Written by Matt Smith, Kristin Mitchell This is a measure of how well your kidneys are working. An estimated GFR test (eGFR) can give your doctor some important information about those organs...
but that’s not enough to predict behavior of the system. Take the EGFR family as an example, a prototypic receptor tyrosine kinase, which has 4 family members that can either homodimerize or heterodimerize when activated, and then activates a large number of signaling pathways...
As little has been done to establish biomarker systems to measure protein–protein based biomarkers in cancer, our group is currently developing PLA that can quantitatively measure defined EGFR protein–protein interactions in lung cancer specimens and relate expression of these interactions to clinical ...
Although providing the potential for rapid comparative analysis of various conditions on myelin production, patterned glass cones do not have the cylindrical geometry of biological axons and cannot be used to measure the ability of OLs to laterally extend and to form Nodes of Ranvier [101]. These...
On the contrary, anti-EGFR agents could improve the expression of VEGF protein, confirming our hypotheses of using this sequence of drugs [17]. The hypoxia induced by an anti-VEGF may lead to molecular and biological changes in cancer cells, thus cells may acquire resistance by living in a ...
However, the same effect could simply be reached by helping the patient to consume 80 g fewer carbohydrates per day instead of using medications that financially burden the healthcare system and have drug-induced adverse effects. A recent study found that SGLT2i treatment led to increased eGFR ...
Since cells are where metabolism happens, it seems natural to explore how the properties of cells may affect metabolism at the tissue, organ, and whole-body levels. Cells are not only the 'building blocks of life', but also the 'energy factories of life'. Hence, the purpose of my essay...
Allogeneic CAR T-cells could also result in GVHD, however, and therefore there is an even more stringent need to implement safety measures, ideally a suicide gene, because it currently represents the only effective safety measure validated in clinical trials of unmodified DLI. Since suicide gene ...