Although EGFR expression has been associated with trastuzumab resistance in cell line models (Kumar, 2007; Dua et al, 2010), previous biomarker studies of EGFR had not validated this observation in human tumours (Gori et al, 2009). In part, this could be due to challenges associated with mea...
Luciferase stable U87MG/ΔEGFR Cells is a luciferase expressing cell line derived from U87MG/ΔEGFR cells. The expression of luciferase has been confirmed with luciferase assay. All clones are puromycin (0.7ug/ml)-resistant. Luciferase stable U87MG/ΔEGFR cells can be a very useful cell line ...
residues was not observed when expression of both Fyn and Yes were simultaneously reduced in the same cell (Fig.3D). Expression analysis by quantitative RT-PCR showed that, in addition to Src, Fyn and Yes, A431 cells express the SFK Lyn but not Lck, Fgr, Hck and Blk (Fig.3C). A co...
[31] Endoh H, Yatabe Y, Kosaka T, et al. PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung cancer patients[J]. J Thorac Oncol (2006) 1:629-34.
cell lines to evaluate the role of ciRS-7 in cell line behavior. The ciRS-7 interfere RNA (siRNA) and its empty vector were transfected into PDAC cells. PDAC cells proliferation and invasion abilities were detected by MTT assay and invasion analysis. The expression of proteins was assessed by...
[8] Chen K, Cheng G, Zhang F, et al. PD-L1 expression and T cells infiltration in patients with uncommon EGFR-mutant non-small cell lung cancer and the response to immunotherapy[J]. Lung Cancer, 2020,142:98-...
NNMT expression and enzyme activity in established glioblastoma cell lines and glioblastoma stem-like cells via the p38 mitogen-activated protein kinase pathway... M Li,C Chen - Neuro-Oncology 被引量: 0发表: 2023年 ANTIBODIES TARGETING GLIOBLASTOMA STEM-LIKE CELLS AND METHODS OF USE THEREOF The ...
NCI H- 522 cells were transfected with EGFR gene converting it into a cell-line with simultaneous EGFR and HER2 over-expression. RESULTS: There were dose dependent significant inhibition of cell proliferation in both NSCLC cells in response to ERRP and the effect started at 24 hours and was ...
We next examined the relationship between RanBP6 and EGFR expression in GBM. In human GBM tumor sections, we observed an inverse correlation between RanBP6 and EGFR protein levels (Supplementary Fig. 8) and RanBP6 knockdown upregulated EGFR expression in the human GBM cell line LN18 (Supplementa...
cell cycle-related genes were altered when knocking down GRHL1. We further demonstrated that GRHL1 could regulate the expression of cell cycle-related genes by binding to the promoter regions and increasing the transcription of the target genes. Besides, we also found that EGF stimulation could ...