Interestingly, these samples were enriched for co-occurring activating PIK3CA mutations, which we demonstrate to reduce sensitivity to osimertinib in vitro in EGFR-mutant cell lines. Overall, our results shed light on the implications of T790M subclonality in advanced-stage NSCLC patients and its ...
(Lower Left panel) Bars show the qRT-PCR-determined U2AF2 E2/E3 ratios in NCI-H522 and NCI-H1299 cells, and in the KRAS and EGFR mutant cell lines, relative to the shControl±SD. (Lower Right panel) Bars show the shIWS1-induced percent reduction of ERK-phosphorylation in the same ...
Preclinical studies have reported that osimertinib was active in EGFRex20ins mutant cell lines and tumor xenografts with a wide therapeutic window [26,27,28,29]. However, whether the preclinical activity of osimertinib could translate into clinical effect remains unclear. Herein, we explored the ...
[10].Lee JY, Ku BM, Lim SH, et al. The BIM Deletion Polymorphism and its Clinical Implication in Patients with EGFR-Mutant Non-Small-Cell Lung Cancer Treated with EGFR Tyrosine Kinase Inhibitors. J Thorac Oncol. 2015;...
[摘要]头颈部鳞状细胞癌(squamous cell carcinoma of the head and neck,SCCHN)是最常见的一类头颈部肿瘤。由于早期症状不典型,大多数SCCHN患者确诊时已处于局部晚期。以标准剂量顺铂为基础的同期放化疗(chemoradiotherapy,CRT)是局部晚期SCC...
Purpose/Objective(s) The role of stereotactic body radiotherapy (SBRT) on the advanced EGFR-mutant non-small cell lung cancer (NSCLC) treated by first-line EGFR-TKIs was still unclear. This study aimed to explore the efficacy and safety of SBRT plus first-line EGFR-TKIs in advanced EGFR-...
mutant lung adenocarcinomas, suggesting the predictive value of these two mutations in SCLC transformation [95,96]. Although concurrent RB1 and TP53 alterations do not represent small cell transformation, it is necessary to determine histologic type using tissue biopsy in the cases of the emergence ...
特别提示:包括重组人表皮生长因子受体(EGFR)(HER1 mutant)在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!产品名称:重组人表皮生长因子受体(EGFR)(HER1 mutant)英文名称:Recombinant Human Epidermal Growth Factor Receptor/Receptor Tyrosine Protein Kinase ErbB1产品货号:JN1439产品规格:10...
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp Cancer Res, 65 (2005), pp. 7276-7282 Google Scholar 42 K Ikeda, H Nomori, Y Ohba...
Cell lines were transfected with EGFR-mutant plasmids and analysed by western blot with antibodies specific for total or phosphorylated-EGFR. Results We found EGFR mutation in 12 of the 71 tumour samples (17%). One tumour contained two mutations. One mutation (p.R776G) was present as a ...