A sample of cancer cells from a biopsy or surgical removal of cancerous tissue; a blood sample drawn from a vein (liquid biopsy) may be used in some situations. Test Preparation Needed? In many cases preparation is minimal, but it will depend upon how the cancer cells are being obtained....
Based on the final score reflecting the hazard of missense mutations, a cutoff value of 0.800 was used, meaning that missense mutations with a score above 0.8 are pathogenic [23]. Mutation Taster evaluates the pathogenic potential of mutations by analyzing DNA sequence alterations [24, 25]. The...
Meaning Ivonescimab plus chemotherapy significantly improved progression-free survival with tolerable safety profile in patients with non–small cell lung cancer who previously underwent EGFR-TKI treatment and may offer a new treatment option for patients with TKI resistance. Abstract Importance For patient...
Meaning Combination therapy with osimertinib and bevacizumab met its primary end point for effectiveness, and a randomized phase 3 trial of osimertinib vs osimertinib and bevacizumab is moving forward. Abstract Importance The combination of erlotinib and bevacizumab as initial treatment of epidermal growth...
Here we present a digital PCR based liquid biopsy for EGFR T790M detection from blood samples with a low detection limit of 0.1% mutant allele frequency. The assay shows 100% concordance with test results obtained from cFDA approved ARMS PCR based EGFR mutation detection assay on FFPE tissue ...
“Often, patients with EGFR-mutated NSCLC develop resistance to treatment during the course of therapy. Resistance in patients is typically diverse and polyclonal, meaning their tumors can have more than one type of resistance caused by different pathways. These variables can make their...
Plain language summary: Different prognostic meaning of tumor resistant gene detected from tumor or blood in patients with EGFR-mutant lung cancer The study demonstrates that patients with EGFR-mutant lung cancer who develop resistance due to a secondary T790M mutation, defined b...
(Qiagen, Hilden, Germany) according to the blood and body fluid spin protocol in the manufacturer's instructions, with the following protocol modifications. The same column was used repeatedly until the whole sample had been processed. The DNA obtained was eluted in 50 μl of sterile bi-...
(i.e., meaning “including, but not limited to,”) unless otherwise noted. Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate ...
options is understood to fall within the meaning, and therefore satisfy the requirement of the term “and/or” as used herein. Concurrent applicability of more than one of the options is also understood to fall within the meaning, and therefore satisfy the requirement of the term “and/or.”...