M-CAP eliminates a majority of variants of uncertain significance in clinical exomes at high sensitivity. Nat Genet. 2016;48(12):1581–6. PubMed CAS Google Scholar Kong X, Zhong X, Liu L, Cui S, Yang Y, Kong L. Genetic analysis of 1051 chinese families with Duchenne/Becker muscular ...
(i.e., meaning “including, but not limited to,”) unless otherwise noted. Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate ...
It is to be understood that the terminology used herein is for describing particular embodiments only and is not intended to be limiting. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to ...
Targeting epidermal growth factor receptor (EGFR) is an appealing strategy for the treatment of NSCLC, because EGFR has been found to be expressed, sometimes strongly, in NSCLC (Franklin et al, 2002). Gefitinib (‘Iressa’, AstraZeneca) is a small molecule and selective EGFR tyrosine kinase in...
In this study, we provided a detailed assay design for EGFR T790M mutation detection in blood samples using a chip-based dPCR system. The assay was shown to have high specificity and sensitivity. High concordance with ARMS PCR on FFPE tissue samples suggested a possible candidate for clinical ...
Blood: Epub ahead of print. 9. Al-Ali B K, Heinrich M C, Lange T, Krahl R., Mueller M, et al. (2004) High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib. Hematol J ...
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Although any methods and materials similar or equivalent to those described herein can also be used in the pr...
Herein, the term “co-administration” and “combined administration” may be used interchangeably (i.e., have the same meaning). The “c-Met” or “c-Met proteins” refer to receptor tyrosine kinases that bind to hepatocyte growth factors (HGF). The c-Met proteins may be those derived ...
(e) The number of blood vessels in each tumor was determined by immunolabeling for CD31 in the same sections from the four groups of mice, with number of blood vessels quantitated per 40× field. Statistics: Student's t-test with Bonferroni's correction. Each treatment compared with DMSO ...
Together, our results suggest that there is crosstalk among cytokines, tumor cells, and the immune microenvironment, and they highlight the paradoxical oncogenic properties of CXCL10 in EGFR-mutant lung cancer during EGFR-TKI therapy. Compared to previous studies aimed at studying EGFR-TKI resistance...