The clinical phenotype can be explained by specific defects in vesicle trafficking along the endolysosomal degradation pathway in the TPC2 À / À mouse. In the absence of TPC2, receptors and cargoes such as LDL or EGF/EGFR, which are transported along the degradation pathway, accumulate ...
A variety of other drug targets identified in the current study are known to act on various other receptors (estrogen, vesicular monoamine transporters, kainate, androgen, Pregnane X, VEGFR, EGFR, Calcium channels) and enzymes (cyclooxygenase, Raf Kinase, Src Kinase, Phosphodiesterases, and Histone...
Before the slaughter on day 90, blood samples were collected from jugular vein into 5-mL endotoxin free vacuum blood collection tubes and were then put into 37 °C water bath for 15 min and centrifuged at 3500 × gfor 15 min at 4 °C for serum collection. Based on the mean values...
Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial JAMA, 294 (2005), pp. 2455-2464 CrossrefView in ScopusGoogle Scholar [48] D.C. Nieman, B.C. Underwood, K.M. Sherman, K. Arabatzis, J.C. Bar...
Chronic kidney disease was defined as a deterioration of at least 30% in the estimated glomerular filtration rate (eGFR)—-the rate at which kidneys remove waste and extra water from blood to make urine—to less than 60 ml/min. The average total weekly tally of moderate to vigorous physical...
Of note, the weaker associations of eGFR and albuminuria for progressive CKD in comparison with the two other kidney outcomes can be partially explained by misclassification of the outcome and regression to the mean. Some limitations of this meta-analysis should be mentioned. First, we included ...
KEYTRUDA, as a single agent, is indicated for the treatment of patients with metastatic NSCLC whose tumors express PD-L1 (TPS ≥1%) as determined by an FDA-approved test, with disease progression on or after...
Wounds can be limited to superfificial skin layers or go deeper and affffect the blood vessels, nerves, muscles, ligaments, tendons and even bones in certain severe traumatic conditions. The skin has the ability to heal itself through a complex pro...
capture. The droplet-based approach is preferable for capturing large amounts of cells with low sequencing depth.26However, more technical noise would be present when this strategy is used. Normally, the following steps would be involved: (a) isolate single cells from sample (blood, tissue, ...
In addition, variants associated with eGFR were not associated with vascular traits, such as blood pressure or myocardial infarction. Taken together, these findings suggest that genetic determinants of eGFR may be mediated largely through direct effects within the kidney. Second, despite the specificity...