Interpretation of immunohistochemical results The staining sites of pan-CK, CK5/6, CK7, CK8/18 and EGFR were in cytoplasm [5]. If more than 80% of tumor nuclei show strong positive expression or no expression at all, it is indicative of a p53 mutant; conversely, if the tumor cells show...
The clinical phenotype can be explained by specific defects in vesicle trafficking along the endolysosomal degradation pathway in the TPC2 À / À mouse. In the absence of TPC2, receptors and cargoes such as LDL or EGF/EGFR, which are transported along the degradation pathway, accumulate ...
A variety of other drug targets identified in the current study are known to act on various other receptors (estrogen, vesicular monoamine transporters, kainate, androgen, Pregnane X, VEGFR, EGFR, Calcium channels) and enzymes (cyclooxygenase, Raf Kinase, Src Kinase, Phosphodiesterases, and Histone...
Wounds can be limited to superfificial skin layers or go deeper and affffect the blood vessels, nerves, muscles, ligaments, tendons and even bones in certain severe traumatic conditions. The skin has the ability to heal itself through a complex proce...
KEYTRUDA, as a single agent, is indicated for the treatment of patients with metastatic NSCLC whose tumors express PD-L1 (TPS ≥1%) as determined by an FDA-approved test, with disease progression on or after...
both mice and humans. Excellent tumor-to-background contrast was achieved in the chick CAM, which followed the same pattern of uptake in mice.18F-FDG tumor uptake in ovo, however, was consistently higher than in vivo. This variation could be explained by slower18F-FDG blood clearance in the...
Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial JAMA, 294 (2005), pp. 2455-2464 CrossrefView in ScopusGoogle Scholar [48] D.C. Nieman, B.C. Underwood, K.M. Sherman, K. Arabatzis, J.C. Bar...
Blood parameters including haemoglobin (g/dL), leukocytes (thousand/μL), thrombocytes (thousand/μL), thyroid-stimulating hormone (TSH) (μU/L), serum creatinine (mg/dL), estimated glomerular filtration rate (eGFR; mL/min/1.73 m2), total cholesterol (TC; mg/dL), high-density lipoprotei...
In addition, variants associated with eGFR were not associated with vascular traits, such as blood pressure or myocardial infarction. Taken together, these findings suggest that genetic determinants of eGFR may be mediated largely through direct effects within the kidney. Second, despite the specificity...
capture. The droplet-based approach is preferable for capturing large amounts of cells with low sequencing depth.26However, more technical noise would be present when this strategy is used. Normally, the following steps would be involved: (a) isolate single cells from sample (blood, tissue, ...