J. et al. Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results. Nat Med (2024) https://doi.org/10.1038/s41591-024-02893-z. Download references Acknowledgements This work was supported by Swim Across America (B.D.C.), The...
Co-culturing Epidermal Growth Factor Receptor (EGFR) CAR-T cells with glioblastoma cells transfected with sgRNA for CRISPR screening demonstrated that the IFN-γ-R signaling pathway confers greater resistance to CAR-T cell killing in glioblastoma and other solid tumors, but not in leukemia and ...
In particular, TLR9 expression in plasma cells correlated with ESR, CRP, serum creatinine, eGFR, and Birmingham Vasculitis Activity Score. To further explore the effect of HMGB1 on B cell, peripheral blood mononuclear cells (PBMCs) from AAV patients were isolated. After stimulated with HMGB1, ...
To confirm that SEED integration could disrupt TCR surface expression, we edited T cells with a TRAC intron-targeted ribonucleoprotein (RNP) and an adeno-associated viral vector (AAV6) encoding a SEED HDRT for a CD19-specific CAR and a truncated epidermal growth factor receptor (EGFRt) tag ...
(EGFR) or the tumour-associated antigen CD276, which are overexpressed in glioblastoma. With respect to T cells with a CAR using an antibody-derived single-chain variable fragment as antigen-binding domain, the designed binders on CAR T cells promoted the proliferation of the cells, the ...
miR-30b-5p suppresses the progression and metastasis of PTC by targeting GALNT7 and subsequently inhibiting the EGFR/PI3K/AKT pathway [128] (Fig.4). PI3K/AKT is also an important metastasis-related signalling pathway in ATC and PDTC, and PIK3CA mutation contributes to the recurrence and metasta...
Examples include cetuxmiab (Erbitux; Bristol-Myers Squibb), an anti-EGFR antibody that is contraindicated in tumors bearing KRAS mutations, and Vemurafenib (Zelboraf; Daiichi-Sankyo), a small-molecule BRAF inhibitor that is effective against tumors bearing BRAF mutations (Hyman et al., 2015). ...
Older age, longer duration of AUD, anemia, a higher erythrocyte sedimentation rate, elevated gamma-glutamyl transpeptidase, increased blood glucose, advanced liver fibrosis (FIB-4325), and a low eGFR (under 60 mL/min) were observed in association with HypoMg. Analysis of multiple factors revealed...
miR-30b-5p suppresses the progression and metastasis of PTC by targeting GALNT7 and subsequently inhibiting the EGFR/PI3K/AKT pathway [128] (Fig.4). PI3K/AKT is also an important metastasis-related signalling pathway in ATC and PDTC, and PIK3CA mutation contributes to the recurrence and metasta...
This study describes the development of an anti-EGFR antibody prodrug (probody) that is locally activated in the tumour microenvironment and has the potential to improve treatment safety. PubMed Google Scholar Pardoll, D. M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev....