The expression of serum sEGFR, sFlt-1, sEndoglin and PLGF in preeclampsia. Pregnancy Hypertens 13, 127-132 (2018). Article PubMed Google Scholar Cui, L, Shu, C, Liu, Z, Tong, W, Cui, M, Wei, C, et al. Serum pr
Drugs with a minimal impact on blood pressure (i.e., SGLT2i) or novel oral inotropes without a direct effect on blood pressure (i.e., omecamtiv mecarbil or istaroxime) may be useful in patients with advanced HF, although the evaluation for potential candidacy to heart transplant or left...
To invade these cells, gonococci interact with heparin sulphate proteoglycan (HSPG) receptor leading to activation of epidermal growth factor receptor (EGFR). The activation of EGFR-associated signaling pathways leads to a decreased expression of integrin, increased β-catenin phosphorylation, and E-...
J. et al. Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results. Nat Med (2024) https://doi.org/10.1038/s41591-024-02893-z. Download references Acknowledgements This work was supported by Swim Across America (B.D.C.), The...
Co-culturing Epidermal Growth Factor Receptor (EGFR) CAR-T cells with glioblastoma cells transfected with sgRNA for CRISPR screening demonstrated that the IFN-γ-R signaling pathway confers greater resistance to CAR-T cell killing in glioblastoma and other solid tumors, but not in leukemia and ...
This is not biologically realistic; the experimental data in drug-naive melanoma cells for mRNA counts display different degrees of skewness of the distribution for different genes (e.g., epidermal growth factor receptor [EGFR] versus Jun, Figure S3A) (Shaffer et al., 2017). These experimental...
In particular, TLR9 expression in plasma cells correlated with ESR, CRP, serum creatinine, eGFR, and Birmingham Vasculitis Activity Score. To further explore the effect of HMGB1 on B cell, peripheral blood mononuclear cells (PBMCs) from AAV patients were isolated. After stimulated with HMGB1, ...
4248.8 GRB2 916 Growth factor receptor bound 2 SOS1 125 Son of sevenless homolog 1 32 44.9 10232 6438.3 CCNA2 109 Cyclin A2 CDK2 286 Cyclin-dependent kinase 2 31 84.3 3485 3064.8 EGF 76 Epidermal growth factor EGFR 626 Epidermal growth factor receptor 31 68.2 5211 3927.8 NFKBIA 231 Nucl....
Nucleic acids were extracted from collected PEmaxKO cells using the NucleoSpin Blood XL kit, treated with RNase A and SPRI purified to obtain purified gDNA. epegRNA–target cassettes were PCR amplified and indexed as described for the initial self-targeting screen (lDS004).StopPR screen (lAC...
Examples include cetuxmiab (Erbitux; Bristol-Myers Squibb), an anti-EGFR antibody that is contraindicated in tumors bearing KRAS mutations, and Vemurafenib (Zelboraf; Daiichi-Sankyo), a small-molecule BRAF inhibitor that is effective against tumors bearing BRAF mutations (Hyman et al., 2015). ...