Your kidneys filter creatinine from the blood into the urine and reabsorb almost none of it. The serum creatinine is then used to estimate the GFR (eGFR) based on a formula. Why Creatinine Tests Are Done Doctors use serum creatinine and eGFR to check how well your kidneys work. As kidney...
144,145 Inhibition of the activity of these receptors results in the suppression of downstream oncogenic signaling cascades including those engaging mitogen-activated protein kinase and phosphatidylinositol-3-kinase.146 Dp strongly inhibited the protein tyrosine kinase activity of all tested RTKs (EGFR, ...
When the EGFR protein is found at high levels in cancer cells, it causes them to grow and divide—making the disease more aggressive. Drugs that block EGFR work by binding to certain parts of the EGFR protein to slow down or stop cell growth. Advanced stomach and oesophageal cancers are us...
Even after incorporating progressive factors such as time-averaged proteinuria, hypertension, and eGFR, the serum Gd-IgA1 level could still predict progression of IgAN. However, that study was performed before the Oxford classification was adopted and used the Haas classification. A subsequent study ...
: Supp5-eGFR and proteinuria correlated down genes. Detailed information of the eGFR and proteinuria correlated downregulated genes Additional file 6 : Supp6-ceRNA network. Detailed mRNA, miRNA and cirRNA gene information of the ceRNA network. Additional file 7 : Supp7-CMAP results. Detailed infor...
Although blood-based AD biomarkers have great potential in the diagnostic work-up of AD, they are not currently useful in routine clinical practice. Despite the numerous studies on various AD-related blood biomarkers in recent years, few have evaluated the classification value of a combination of ...
Additional Contributions: We thank the staff and participants of the Strong Heart Study, Women’s Health Initiative, Framingham Heart Study, and Atherosclerosis Risk in Communities Study for their important contributions making this work possible, as well as the Cohorts for Heart and Aging Research in...
Synergistic effects of metformin in combination with EGFR-TKI in the treatment of patients with advanced non-small cell lung cancer and type 2 diabetes. Cancer Lett. 2015;369(1):97-102, http://dx.doi.org/10.1016/j.canlet.2015.08.024. 126. Li L, Han R, Xiao H, Lin C, Wang Y, ...
In this regard, the severity of AKI [47, 48] and the baseline eGFR [49] in the group non PI-BUN/Cr & AKI were critical factors that could impact in the prognosis and survival of this patients. This differentiation based on PI-BUN/Cr is similar in some results to that described by ...
"We were really asking a question on behalf of patients," Reck said: "Is there a valid test that can identify an EGFR mutation and give me the opportunity for superior treatment, even if my lung tumour is not accessible for bronchoscopy or CT-guided biopsy? And, are the results of this...