Secondary end points were the highest price of osimertinib that still sustained high cost-effectiveness, the number of life-years saved, and the cost of each life-year saved. In addition, deterministic sensitivity analyses were performed to test the robustness of the results and to assess strategie...
The Implicit Association Test (IAT) was employed to measure mothers' implicit moral identity, and adolescents' prosocial conduct was evaluated by means of a donation task; all other characteristics of mothers and adolescents were acquired via self-reporting. The data analysis was based on a cross-...
International survey showed high global EGFR testing rates prior to first-line lung cancer therapy but highlighted a shortfall in the number of test results received before deciding on therapy Nearly one in five patients are at risk of missing out on treatments personalised to their specific lung c...
PKCα、PCNA、GFAP、EGFR在脑胶质瘤中的表达及临床意义 【摘要】 目的 探讨蛋白激酶Cα、增殖细胞核抗原、胶质纤维酸性蛋白、表皮生长因子受体的表达、相互关系及其意义。方法 采用免疫组织化学法,检测55例脑胶质瘤标本中PKCα、PCNA、GFAP和EGFR的表达。结果 PKCα、PCNA和EGFR的表达随胶质瘤病理分级的增加而增高,而...
10, 24, 25, 26 Our test results on the patient cohort showed no significant inconsistency with the reported results. Further studies should recruit more patients to make all results statistically more accurate. 4. Discussion 4.1. The dPCR assay offers high specificity and sensitivity for EGFR ...
Kidney Function Assessment: The Need for a Confirmatory Test: Confirmation of Creatinine-Based eGFR Should Be Performed in Select Circumstances Using, Where Appropriate, Either Measured GFR or Cystatin CInker, Lesley A
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as those commonly understood by one of skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control. Although methods and materials...
Body mass index (BMI) influences the prognosis of patients with non-small cell lung cancer (NSCLC), including both early-stage and late-stage NSCLC patients that are undergoing chemotherapies. However, earlier research on the relationship between BMI and
Despite the high sensitivity of EGFR-mutated patients to EGFR-TKIs, the objective response rate is of about 70–80% for 1st, 2nd and 3rd generation TKIs [2,3,5], meaning that a portion of patients do not respond to EGFR-TKI treatment, notwithstanding the presence of sensitizing EGFR ...
In this group, which did test positive for T790M by tissue, the ORR was 64% and the median PFS was 15.2 months. “When we studied the tumor results on patients who were T790M-negative in the blood we could differentiate those who do better or worse on osimertinib, meaning that a biopsy...