Non-squamous NSCLC cases with EGFR-sensitizing mutations were treated with anlotinib and icotinib. The primary endpoint was progression-free survival (PFS). Secondary endpoints included the objective response rate (ORR), disease control rate (DCR), overall survival (OS), and toxicity. Results Sixty...
A sample of cancer cells from a biopsy or surgical removal of cancerous tissue; a blood sample drawn from a vein (liquid biopsy) may be used in some situations. Test Preparation Needed? In many cases preparation is minimal, but it will depend upon how the cancer cells are being obtained....
Meaning Combination therapy with osimertinib and bevacizumab met its primary end point for effectiveness, and a randomized phase 3 trial of osimertinib vs osimertinib and bevacizumab is moving forward. Abstract Importance The combination of erlotinib and bevacizumab as initial treatment of epidermal growth...
The results of the first planned interim analysis are reported. Results Among 322 enrolled patients in the ivonescimab and placebo groups, the median age was 59.6 vs 59.4 years and 52.2% vs 50.9% of patients were female. As of March 10, 2023, median follow-up time was 7.89 months. ...
“Often, patients with EGFR-mutated NSCLC develop resistance to treatment during the course of therapy. Resistance in patients is typically diverse and polyclonal, meaning their tumors can have more than one type of resistance caused by different pathways. These variables can make their...
including a platinum agent. The results of the evaluation showed that seven of the 27 patients who received gefitinib therapy had a PR and seven had SD. The other 13 patients had progressive disease (PD). DNA was extracted from all 43 samples of pleural effusion fluid. Amounts of the DNA...
Here we present a digital PCR based liquid biopsy for EGFR T790M detection from blood samples with a low detection limit of 0.1% mutant allele frequency. The assay shows 100% concordance with test results obtained from cFDA approved ARMS PCR based EGFR mutation detection assay on FFPE tissue ...
(i.e., meaning “including, but not limited to,”) unless otherwise noted. Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate ...
It is to be understood that the terminology used herein is for describing particular embodiments only and is not intended to be limiting. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to ...
Osimertinib and chemotherapy provide similar OS benefits in patients with T790M-positive tumors. Plain language summary: Different prognostic meaning of tumor resistant gene detected from tumor or blood in patients with EGFR-mutant lung cancer The study demonstrates that patients wit...