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Blood-based testingCobas assayEGFR mutationErlotinibObjective: Patients with advanced non-small-cell lung cancer (NSCLC) with an adenocarcinoma component are recommended to undergo epidermal growth factor receptor (EGFR) mutation testing when being considered for EGFR targeted therapy. We conducted an ...
In this study, we provided a detailed assay design for EGFR T790M mutation detection in blood samples using a chip-based dPCR system. The assay was shown to have high specificity and sensitivity. High concordance with ARMS PCR on FFPE tissue samples suggested a possible candidate for clinical ...
p-value was calculated using log -Rank test. (E) Kaplan-Meier overall survival analysis of LUSC TRACERx dataset. Individual tumors stratified as high-, discordant, or low-risk according to the expression profile of CoCu8 signature across multiple regions, as previously described and stratified ...
and normal cells, theEGFRmutation status needs to be evaluated in a pair of DNA specimens from the tumour and pleural effusion fluid to confirm the usefulness of the mutation status determined from pleural effusion fluid. However, it is sometimes difficult to obtain tumour samples from patients ...
or persistent. The ongoing excretion of protein in the urine potentially signifies a significant kidney abnormality. Urine containing an elevated number of red blood cells, medically termed hematuria, is categorized as either gross or microscopic. The glomeruli or supplementary places along the urinary ...
It is known in the prior art that small but significant amounts of normal DNA circulate in the blood of healthy people and this amount has been found to increase in cancer states. The prior art contains disclosure that mutant oncogene DNA could be detected in peripheral blood plasma or serum...
(1998) Identification of Multiple Forms of 180-kDa Ribosome Receptor in Human Cells, DNA and Cell Biology, 17(5):449-460. Lee et al. (2000) “Targeting Rat Anti-Mouse Transferrin Receptor Monoclonal Antibodies through Blood-Brain Barrier in Mouse”, The Journal of Pharmacology and ...
Impact of Sample Collection Method for EGFR Mutation Testing: Results of Blood-Based and Tissue-Based cobas EGFR Mutation Testing in the Treatment of Locally Advanced or Metastatic NSCLC in the US Poulios N1, Hristova-Neeley D2, Gavaghan M2...
Blood, vol. 120, No. 21, pp. 4595 (2012). Johnson et al., Impact of NRAS Mutations for Patients with Advanced Melanoma Treated with Immune Therapies. Cancer Immunol Res, 3(3):288-295 (2015). Rudnick et al., IT-020: A dramatic clinical and cytologic response to ipilimumab in a ...