Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a programme of proliferation that is closely linked with the acquisition of effector functions and leads ultimately to memory-cell formation. Here, we discuss the signals required for commitment to this ...
Immunological memory is a cardinal feature of adaptive immunity and an important goal of vaccination strategies. Here we highlight advances in the understanding of the diverse T lymphocyte subsets that provide acute and long-term protection from infectio
Immunological memory is an important characteristic of adaptive immune response and elucidation of its cellular basis is critical for vaccine exploration and disease prevention. Recent studies have shown that memory T cells could be divided into central memory T cells and effector memory T cells, which...
Andreas P Russ6, Tullia Lindsten3, Jordan S Orange2, Ananda W Goldrath7,8, Rafi Ahmed4 & Steven L Reiner1 Two seemingly unrelated hallmarks of memory CD8+ T cells are cytokine-driven proliferative renewal after pathogen clearance and a latent effector program in anticipation of rechallenge. ...
Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a programme of proliferation that is closely linked with the acquisition of effector functions and leads ultimately to memory-cell formation. Here, we discuss the signals required for commitment to this programm...
There is also heterogeneity within antiviral T cell populations, and subsets of effector and memory T cells now permeate our thinking about specialization of T cell responses to pathogens. It has been less clear, however, how heterogeneity in developing virus-specific effector and memory T cells ...
There is now considerable evidence suggesting that CD8+ T cells are able to generate effector but not functional memory T cells following pathogenic infections in the absence of CD4+ T cells. We show that following transplantation of allogeneic skin, in the absence of CD4+ T cells, CD8+ T ce...
1) Effector/memory T cells 效应/记忆T细胞2) effector memory T cell 效应记忆性T细胞 1. Based on the ability to express chemokine receptor CCR7 and the phosphatase CD45RA,T cells can be divided into na(l|¨)ve T cells,central memory T cells(T_(CM) cells),and effector memory T cells...
While it is now widely accepted that these diverge from a common source of nave T cells (Tn), the developmental relation and succession of effector and memory T cell subsets is still under intense debate. Recently, a distinct memory T cell subset has been suggested to possess stem cell-like...
1) effector memory T cell 效应记忆性T细胞 1. Based on the ability to express chemokine receptor CCR7 and the phosphatase CD45RA,T cells can be divided into na(l|¨)ve T cells,central memory T cells(T_(CM) cells),andeffector memory T cells(T_(EM) cells). ...