Conclusion Taken together, these data strengthen our understanding of T-cell effector function, highlight the multiple involvement of different cell surface ligands in cell-cell contact and, provide novel insights into the pathogenesis of inflammatory RA disease.Introduction...
(LP) necessitates mechanical and enzymatic disruption of tissue, which could alter the phenotype of isolated cells and may pref- erentially purify particular cell types.1 Second, macrophages share many phenotypic characteristics with DCs, rendering surface marker expression alone inappropriate for une...
(C) gp33-Db tetramer-binding CD8+ T cells from spleen and lymph nodes were stained with the indicated markers 1 month after infection with LCMV. Data is representative of four experiments (n = 12). See also Figure S1. Examination of other cell surface markers revealed striking differences ...
Survival, surface marker expression, and proliferation rate of anergic, effector/memory-like (EML), and naïve CD4+ T cells.Yrina RochmanMasashi YukawaAndrey V. KartashovArtem Barski
FASN (Fatty Acid Synthase) expression is found upregulated in several kinds of cancers and considered as a prognostic marker [27,28]. FAS is also essential for effector T cell proliferation and differentiation due to supplying sufficient lipid for membrane components. Notably, pharmacologic or ...
Soluble CD52 was also used by the cell as an effector molecule for suppression.4 Therefore, the CD52 molecule is both a surface marker and an effector molecule of this novel regulatory T-cell subset. This is a preview of subscription content, access via your institution Access options ...
Glycosylation changes on surface molecules of T cells affect cell trafcking and function and may be useful in discriminating between naive, effector, and memory T cells. To analyze oligosaccharide structures on T cells activated in vivo, we examined alterations in sialic acid residues on T cells ...
Increased populations of regulatory T cells (Tregs) impair anti-tumor immunity. Recently, the transcription factor Foxp3 has been reported to play a key role in CD4 +CD25 + regulatory T cell function and represents a specific marker for these cells. However, Foxp3 is a nuclear protein and is...
Although mouse Thpp-like cells have also been identified among spleen and particularly lymph node cells, further characterization of these cells has been difficult without a defining cell surface marker. Using Affymetrix GeneChips followed by FACS analysis, we found that in vitro-derived Thpp cells ...
CAR NK cells as vehicles for engineered “off-the-shelf” cellular cancer immunotherapy have attracted significant interest. Nonetheless, a comprehensive comparative assessment of the anticancer activity of CAR T cells and CAR NK cells carrying approved