To provide means for finding a marker molecule having high effector control T-cell selectivity to specifically detect an effector control T-cell.SOLUTION: An effector control T-cell is detected from among samples containing T-cells using, as an indicator, expression of (i) CXCR6 positive and (...
All of the PNA high CD8 T cells from infected mice were CD44 high , indicating that glycosylation changes were occurring on activated T cells. There was also an increase in the PNA high CD4 T cell population in virally infected mice. Increased PNA binding to activated CD8 T cells correlated...
Regulatory T (T(reg)) cells are a subset of CD25(+)CD4(+) T cells that constitutively express high levels of cytotoxic T lymphocyte antigen-4 (CTLA-4) and suppress T-cell activation and effector functions. T(reg) cells are increased in tissues of individuals infected with HIV-1 and maca...
addition, we show that Blimp1 controls common and unique aspects of Treg and Teff cell function by differentially regulating gene expression in these T cell subsets. These findings document previously unappreciated aspects of Blimp1’s role in T cell biology and shed light on the intricate mechanis...
CCR4, a chemokine receptor, is considered a preferential marker for Th2 cells. Another chemokine receptor, CCR7, is regarded to be a suitable molecule for T-cell homing to lymph nodes. Recent studies have demonstrated that memory T cells are subdivided into central memory T cells (TCMs) and ...
Massive production of Th2 cytokines by human CD4+ effector T cells transiently expressing the natural killer cell marker CD57/HNK1. Immunology. 1997;91:541-7 pubmedBrinkmann V, Kristofic C. Massive production of Th2 cytokines by human CD4+ effector T cells transiently expressing the natural ...
. CD8+T cell depletion also partially rescued the growth inhibition of HIF-1α (Del) tumors but to a lesser extent (Fig.3Band Supplementary Fig.1D). These results highlight the major contribution of NK cells, but they do not exclude the role of CD8+T cells, in the inhibition of HIF-...
These nucleotide antagonists do not cross the cell membrane and are specific for ecto-ATPase in T cells, B cells and NK cells. Inhibition of ecto-ATPase by both reversible and irreversible nucleotide ant agonists results in the inhibition of antigen induced cytokine secretion and cytolytic activity...
Increased populations of regulatory T cells (Tregs) impair anti-tumor immunity. Recently, the transcription factor Foxp3 has been reported to play a key role in CD4 +CD25 + regulatory T cell function and represents a specific marker for these cells. However, Foxp3 is a nuclear protein and is...
Forkhead box P3 (FOXP3) is considered a specific marker for CD4+CD25+ regulatory T (Treg) cells, but increasing evidence suggests that human CD4+CD25− effector T (Teff) cells can transiently express FOXP3 upon activation. We demonstrate that the signal transducer and activator of transcription...