Expression of effector T-cell markers of B19V NS1-specific T-cells.Mathias StreitzMichel NoutsiasRudolf VolkmerMaria RohdeGordon BrestrichAndrea BlockKatrin KlippertKatja KotschBernhard AyMichael Hummel
These T(eff) cells in the periphery simultaneously produce IL-10 and proinflammatory cytokines and express lineage markers characteristic of conventional T helper type 1 or T cytotoxic type 1 cells. Notably, blocking the action of the T(eff) cell-derived IL-10 results in enhanced pulmonary ...
Antigen-specific effector T cells are prerequisite to immune protection, but because of the lack of effector cell-specific markers, their generation and di... N Manjunath,P Shankar,B Stockton,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: ...
Unpaired t test was used. These experiments were performed at least twice with similar results. Bars, mean; error bars, s.e.m. Extended Data Fig. 3 Treg cell activation markers are down-regulated by PD-1 signaling and recovered by anti-PD-1 mAb. (a, c) Representative FCM staining (...
d Immunoblots for CAR expression in exosomes compared with cell markers for endoplasmic reticulum (calregulin), Golgi (Golgi 58 K), mitochondrial (prohibitin), or nuclear (nucleoporin p62) markers. e Flow cytometry analyses of CAR exosomes linked to latex beads (4-mm diameter) or CAR-T ...
T regs that have manageable markers G AD 65 fo r 7 days.Single—cell clones were gen erated from T cells sep arated in to four groups b ased on the expression and antigen specifi city has important levels of CD 52 (top 5,1 0,20 or bottom theoretical and p ractic al im...
T cells from regional draining lymph nodes (LNs) of DED mice and normally sighted mice were analyzed for surface activation markers (CD69 and CD154), chemokine and cytokine receptors, and proliferation potential. Draining LNs of DED mice showed increased frequencies of CD69- and CD154-expressing...
CD8(+) FOXP3(+) T cells did not express markers of regulatory [CTLA-4, CCL4, interleukin-10 (IL-10), transforming growth factor-β1], exhausted (PD-1), or senescent (CD57) CD8(+) T lymphocytes. Instead, this subset showed an antigen-experienced "EM1" phenotype (CCR7(-) CD45RA(...
Boosting T cell activation through costimulation directs defense against cancer and viral infections. Despite multiple studies targeting costimulation in clinical trials, the increased potency and reprogramming of T cells endowed by costimulation is poor
Core Treg cell genes encoding the effector molecules ICOS, IL10, CTLA4, TNFRSF18, and PDCD1 were associated with increased super-enhancers as well as FURIN and ID2 which are more putative functional Treg cell markers. eTreg cell differentiation was also reflected in the enhancer profile of SF...