Intestinal macrophages: unique effector cells of the innate immune system. Immunol Rev. 2005; 206 :149–159. doi: 10.1111/j.0105-2896.2005.00288.x. [ Cross Ref ]Smith PD, Ochsenbauer-Jambor C, Smythies LE. Intestinal macrophages: unique effector cells of the innate immune system. Immunol...
The effector cells of the innate immune response are phagocytes that can engage with the pathogens either intracellularly, after phagocytosis, or extracellularly by releasing toxic compounds in the close vicinity of the invaders. From:Trends in Parasitology,2022 ...
The naive CD4 T cell is a multipotential precursor with defined antigen recognition specificity but substantial plasticity for development down distinct effector or regulatory lineages, contingent upon signals from cells of the innate immune system. The range of identified effector CD4 T cell lineages ...
Cells of the innate immune system interact with pathogens via conserved pattern-recognition receptors, whereas cells of the adaptive immune system recogniz... LV Kaer,VV Parekh,L Wu - 《Cell & Tissue Research》 被引量: 212发表: 2011年 IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces...
Naïve CD4+ T cells coordinate the immune response by acquiring an effector phenotype in response to cytokines. However, the cytokine responses in memory T cells remain largely understudied. Here we use quantitative proteomics, bulk RNA-seq, and single
Moreover, CAR-T cells are vulnerable to immunosuppressive mechanisms. Here, we report that CAR-T cells release extracellular vesicles, mostly in the form of exosomes that carry CAR on their surface. The CAR-containing exosomes express a high level of cytotoxic molecules and inhibit tumour growth....
Louis, Missouri 63110 bThe directed development of CD4 effector T cells by cytokines elicited from pathogen-activated cells of the innate immune system is a hallmark of adaptive immu- nity. Until recently, the known universe of adaptive CD4 T cell responses has been encompassed by the Th1- Th...
Two prokaryotic defence systems, prokaryotic Argonautes (pAgos) and CRISPR–Cas, detect and cleave invader nucleic acids using complementary guides and the nuclease activities of pAgo or Cas proteins. However, not all pAgos are active nucleases. A large clade of short pAgos bind nucleic acid guides...
However, host cells possess an evolutionarily conserved innate immune response that can sense the pathogen through the activity of its effectors and mount a robust immune response. This "effector triggered immunity" (ETI) was first discovered in plants but recent evidence suggest that the process is...
Innate cytokines are critical drivers of priming and differentiation of naive CD4 T cells, but their functions in memory T cell response are largely undefined. Here we show that IL-1 acts as a licensing signal to permit effector cytokine production by pr