In subject area:Immunology and Microbiology The effector cells of the innate immune response are phagocytes that can engage with the pathogens either intracellularly, after phagocytosis, or extracellularly by releasing toxic compounds in the close vicinity of the invaders. ...
M. Views of immunology: effector T cells. Immunol. Rev. 240, 25-39, doi:10.1111/j.1600-065X.2010.00997.x (2011).Lewinsohn DA, Gold MC, Lewinsohn DM. Views of immunol- ogy: effector T cells. Immunol Rev 2011; 240: 25-39.Lewinsohn DA, Gold MC, Lewinsohn DM (2011) Views of ...
nature nature immunology articles article Article Published: 15 January 2024 BCG immunization induces CX3CR1hi effector memory T cells to provide cross-protection via IFN-γ-mediated trained immunity Kim A. Tran, Erwan Pernet, Mina Sadeghi, Jeffrey Downey, Julia Chronopoulos, Elizabeth Lap...
Nature Immunology22,996–1007 (2021)Cite this article 16kAccesses 104Citations 24Altmetric Metrics Abstract During chronic viral infection, CD8+T cells develop into three major phenotypically and functionally distinct subsets: Ly108+TCF-1+progenitors, Ly108−CX3CR1−terminally exhausted cells and ...
Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately evade control by natural killer (NK) cells remains incompletely defined. Using global transcriptomic and flow-cytometry analyses and genetically engineered mouse models, we identified the cytokine-TGF-β-signaling-de...
European Journal of ImmunologyDavidson, T. S., Shevach, E. M. (2011) Polyclonal Treg cells modulate T effector cell trafficking. Eur. J. Immunol. 41, 2862-2870.Davidson TS, Shevach EM. Polyclonal Treg cells modulate T effector cell trafficking. Eur J Immunol 2011;41:2862-2870....
From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors.doi:10.1155/2011/439053Unraveling the mechanisms used by the immune system to fight cancer development is one of the most ambitious undertakings in immunology. Detailed knowledge regarding the ...
Using IL-17A tracking-fate mouse models, we found that a significant fraction of lung CD4 TRM cells derive from IL-17A-producing effector (TH17) cells following immunization with heat-killed Klebsiella pneumonia (Kp). These exTH17 TRM cells are maintained in the lung by IL-7, produced by ...
Gadeberg OV, Rhodes JM, Larsen SO: The effect of various immunosuppressive agents on mouse peritoneal macrophages and on the in vitro phagocytosis of Escherichia coli O4:K3:H5 and degradation of 125I-labelled HSA-antibody complexes by these cells. Immunology. 1975, 28 (1): 59-70. PubMed ...
The Wnt pathway has a central role in stem cell regulation. Gattinoni et al. now show that activation of the Wnt signaling cascade in naive CD8+ T cells blocks their differentiation into effector T cells and triggers instead a memory stem cell–like phen