Serafini N, Di Santo JP. Effector cells of the mucosal immune system: innate lymphoid cells. In: Mucosal Immunology. Edited by J. Mestecky, W. Strober, M. Russell , H. Cheroutre, B. N. Lambrecht, B. Kelsall, Elsevier 2015Serafini N, Di Santo JP. Effector cells of the mucosal ...
The ‘reinforcement’ of theimmune systemfrom systemic and microenvironmental factors to support the function of effector immune cells: this measures how well the overall microenvironment and other factors could support or suppress the durability of effector cells to kill tumor cells. ...
This occurs besides strong adoptive immune responses and the induction of large numbers of activated pathogen-specific T-cells. The failure of the immune system to clear these viruses is typically attributed to a loss of effector T-cell function—a phenomenon referred to as T-cell exhaustion. ...
The immune system can identify and destroy nascent tumor cells in a process termed cancer immunosurveillance, which functions as an important defense again... MD Vesely,MH Kershaw,RD Schreiber,... 被引量: 443发表: 0年 Evolution of Innate and Adaptive Effector Cell Functions during Acute HIV-1...
Engaging the power of the patient's own immune system to actively seek out and destroy transformed cells holds great promise for cancer therapy. Tumor vaccines offer the potential for preventing cancer in high-risk individuals, preventing disease relapse after diagnosis and initial therapy, and shifti...
The effector/reporter system essentially enables the gene encoding a signal protein and the reporter gene driven by an output signal (i.e., promoter of the gene responding to the signal) to be coexpressed in cells. Thus, any signal proteins as well as transcription factors, such as receptors...
However, host cells possess an evolutionarily conserved innate immune response that can sense the pathogen through the activity of its effectors and mount a robust immune response. This "effector triggered immunity" (ETI) was first discovered in plants but recent evidence suggest that the process is...
Strikingly, intILC1s and ILC1s were unable to control local tumor growth and metastasis, whereas NK cells favored tumor immunosurveillance. Experiments with an antibody that neutralizes the cytokine TNF suggested that escape from the innate immune system was partially mediated by TNF-producing ILC1s....
While the general focus has been placed on manipulation of cytotoxic effector cell populations, we will explore the dual role of leukemia cells as both antigen-presenting and target cells and describe various vaccination strategies to facilitate a protective antileukemic immune response in this setting...
Researchers over the last several decades have tried to determine how our immune system fights Mtb infection. It is known that CD4 T cells, and the pro-inflammatory cytokine, IFNγ, are required to control Mtb infection in humans and in mice. Based on these observations, it is commonly ...