那么到这里我们通过下载数据并整理成R包需要的方式就结束了,然后我们需要使用TwoSampleMR包进行分析 myocardial_exposure_clump<-read_exposure_data(filename="exposure.csv",sep=",",snp_col="SNP",beta_col="beta",se_col="se",effect_allele_col="Effect_allele",other_allele_col="Other_allele",clump=T...
HIV positive individuals heterozygous for a 32 basepair deletion in the CCR5 encoding gene (CCR5 Delta32) have a reduced number of CCR5 receptors on the cell surface and a slower progression towards AIDS and death. Other human polymorphisms, such as the CCR2 64I and the CCR5 promoter -2459...
A genotype distribution similar to other populations was found. The polymorphism is in Hardy–Weinberg, p > 0.05. Changing aspartate to alanine produced a conformational change. Conclusions The study reveals a high frequency of the ancestral allele at rs2291166 polymorphism in the Mexican population....
Conclusions The pharmacokinetics of atomoxetine in healthy Chinese subjects appears comparable to other ethnic populations. Multiple dosing of 80 mg qd atomoxetine was well tolerated in this study. 展开 关键词: atomoxetine Chinese CYP2D6 CYP2D6*10 pharmacokinetics ...
Notably, all of these factors have been linked to inflammation which, when chronic, damages the brain and other organs, particularly among genetically vulnerable individuals (Licastro et al., 2005). In terms of genetic influence on age-related brain changes, perhaps the most widely studied ...
In our analysis, however, no protective effect for NACP allele 2, or any of the other NACP alleles, was observed.doi:10.1002/ana.410440223Nathan E. HellmanElizabeth A. GrantAlison M. GoateJohn Wiley And Sons, Inc.Annals of Neurology
aegypti, as well as in other vector and pest species, may arise through two major mechanisms. The first mechanism consists of metabolic or enzymatic resistance. In this case resistance is achieved through the up-regulation or constitutive overproduction of detoxifying enzymes. They work by rapidly ...
On the other hand, the transcription of three genes encoding c-kit receptor, tryptophan hydroxylase, and granzyme B was markedly reduced inmi/mi CMCs, but the reduction was significantly smaller intg/tg CMCs. These results indicated the inhibitory effect ofmi-MITF on the transactivation of ...
Therefore, the simplest explanation for root:shoot homeostasis in maize (and perhaps other crops) over thousands of years is that as the tiller number was reduced during domestication, there were successively fewer crown root systems because these initiate at the base of tillers. With respect to ...
Similar results were seen at the other alpha values. These results suggest that removal of low MAF SNPs from analysis due to concerns about inflated false-positive results may not be appropriate.TabanginDivisionMeredithDivisionE.DivisionWooDivision...