而后，GO以及KEGG通路富集分析发现细胞外基质（ECM）受体互作通路（ECM-receptor interaction pathway）显著富集（图2）。并且，整合素家族基因（integrins）作为一种ECM受体，在耐药细胞系中的表达显著提高，说明该基因参与的通路被异常激活。然而，这些整合素是如何发挥功能的呢？研究人员首先聚焦到整合素下游激酶Src和Fak。...
The KEGG pathway annotation showed that all DEGs were significantly enriched in 20 pathways, including the ECM-receptor interaction pathway and the protein digestion and absorption pathway, suggesting that there are many DEGs and signaling pathways involved in breast cancer. This is also a major reaso...
The discovery of focal adhension, ECM-receptor interaction and iron uptake pathway might contribute to the understanding of the mechanism and effective therapies for osteoporosis. However, further research on the relation between EMC-receptor interaction and osteoporosis were in need. 展开 ...
Hedgehog signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway View more pathways>> All All Primary antibodies Secondary antibodies Peptides ECM-receptor interaction The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important...
The results revealed that the most abundant pathways among differentially expressed genes in LUAD primarily involved the cell cycle, ECM receptor interaction, protein digestion and absorption, p53 signaling pathway, complement and coagulation cascade, and tyrosine metabolism. Two ECM-associated subtypes ...