研究者们首先建立了体内外双药耐药模型 （图1），通过该模型验证了黑色素瘤双药耐药细胞中代偿通路的激活。而后，GO以及KEGG通路富集分析发现细胞外基质（ECM）受体互作通路（ECM-receptor interaction pathway）显著富集（图2）。并且，整合素家族基因（integrins）作为一种ECM受体，在耐药细胞系中的表达显著提高，说明该...
A key signaling pathway, the ECM-receptor interaction signal pathway, was also identified as possibly involved in the development of breast cancer. Background Breast cancer is the most common malignant tumor and the fifth leading cause of cancer-related death for women in China [1]. The ...
The discovery of focal adhension, ECM-receptor interaction and iron uptake pathway might contribute to the understanding of the mechanism and effective therapies for osteoporosis. However, further research on the relation between EMC-receptor interaction and osteoporosis were in need. 展开 ...
By analyzing interactions among the DEGs by GSEA method, signal path- ways as netrin-1 signaling,iron uptake, cell cycle, focal adhesion, natural killer cell mediat- ed, ECM-receptor interaction were significantly enriched by KEGG enrichment analysis. The pathogenic mechanism of osteoporosis is ...
Hedgehog signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway View more pathways>> All All Primary antibodies Secondary antibodies Peptides ECM-receptor interaction The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important...
receptorinteractionwerehighlyenriched.Thediscoveryoffocaladhension,ECM-receptorinteractionandironuptakepathwaymightcontributetotheunderstandingofthemechanismandeffectivetherapiesforosteoporosis.However,furtherresearchontherelationbetweenEMC-receptorinteractionandosteoporosiswereinneed.Keywords:Osteoporosis,protein-proteininteraction...
Moreover, ligand-receptor interaction and pathway analysis revealed that the DA-ECM High subtype may likely help maintain tumor cell dormancy through MAPK, Hedgehog and Notch signaling pathways. Finally, in silico drug screening against the DA-ECM signature and in vitro assay showed dormant cancer ...
Signaling of receptor tyrosine kinase can also influence the activation and maturation of antigen-presenting cells, impacting the efficiency of MHC class II antigen presentation to T cells. These interactions illustrate coordinated responses to WD intake affecting immune responses and matrix remodeling, ...
Our results revealed that ECM-receptor interaction and ECM organization were both downregulated in the damaged ovaries. Further investigation showed that ECM-related genes were downregulated in the CTX and BUS treatment group and partially rescued in hUMSCs injection group but not in the PBS group. ...
We next investigated the extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling pathway, which mediates the function of a variety of ECM proteins through integrin receptor signaling.34 As illustrated in Figure 4a, overexpression of wild-type Adamts1 activated ERK1/2 signaling, while ...