Previously, we identified 2 ecdysteroid kinase-like (EcKL) genes-Wallflower (Wall) and Pinkman (pkm)-in the model fruit fly Drosophila melanogaster that are orthologs of the ecdysteroid 22-kinase gene BmEc22K. Here, using gene knockdown, knockout, and misexpression, we explore Wall and pkm's ...
Adams, T.S., Hagedorn, H.H., and Wheelock, G.D. (1985). Haemolymph ecdysteroid in the housefly,Musca domestica, during oogenesis and its relationship with vitellogenin levels. J. Insect Physiol.31, 91–97. ArticleCASGoogle Scholar Amdam, G.V., Simões, Z.L.P., Guidugli, K.R.,...
Ecdysterone also causes an influx of calcium ions into the cells, which causes an increase in the phosphorylation of Akt. Akt is a protein kinase that mediates protein synthesis, so if ecdysterone increases its activity, then this could be the mechanism through which it enhances muscle growth.[...
The multidirectional activity of ecdysteroids has raised the question of how these compounds are able to affect that many processes. A plausible hypothesis is that ecdysteroids affect Akt/PKB (protein kinase B) pathway, an intracellular signaling cascade that plays a central role in mammalian cell ...
The lKCs show preferential expression of five genes encoding proteins involved in Ca2+-signaling, such as Ca2+/calmodulin-dependent protein kinase II (CaMKII)19, which plays a central role in the synaptic plasticity that serves as a platform for learning and memory processes in many animal ...
Ecdysteroid-containing plant extracts produced similar results. The effect was inhibited by a phosphoinositide kinase-3 inhibitor, which suggests a PI3K-mediated mechanism. 展开 关键词: ecdysteroid ajuga spinach protein synthesis skeletal muscle myotube C2C12 ...
Stimulation of the PG by neuropeptides involves several signaling cascades, including a cAMP-dependent pathway, a classical mitogen-activated protein kinase cascade, and an S6 kinase pathway (3, 5, 6). These pathways control synthesis of ecdysteroids from dietary cholesterol or phytosterols via a ...
B. The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis. Science 326, 1403–1405 (2009). 22. Nu¨sslein-Volhard, C. & Wieschaus, E. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster I. Zygotic loci on the second ...
The Role of Ecdysteroid 22-Kinase in the Accumulation of Ecdysteroids in Ovary of Silkworm Bombyx mori. Yoichi Ito,Haruyuki Sonobe. Annals of the New York Academy of Sciences . 2009Ito Y, Sonobe H. The Role of Ecdysteroid 22-Kinase in the Accumulation of Ecdysteroids in Ovary of Silkworm ...
Ecdysteroid kinase-like (EcKL) paralogs confer developmental tolerance to caffeine in Drosophila melanogasterdoi:10.1101/2021.09.15.460555Jack L. ScanlanPaul BattlayCharles RobinCold Spring Harbor Laboratory